Dilazep dihydrochloride

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Cat.No. 0481 - Dilazep dihydrochloride | C31H44N2O10.2HCl | CAS No. 20153-98-4
Description: Adenosine uptake inhibitor
Chemical Name: 1,4-bis[3-(3,4,5-Trimethoxybenzoyloxy)propyl]homopiperazine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Coronary and cerebral vasodilator, suppresses the effects of ischemia. Inhibitor of platelet aggregation and of membrane transport of nucleosides. Inhibits adenosine uptake.

Technical Data

M. Wt 677.62
Formula C31H44N2O10.2HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 20153-98-4
PubChem ID 29976
InChI Key VILIWRRWAWKXRW-UHFFFAOYSA-N
Smiles Cl.Cl.COC1=CC(=CC(OC)=C1OC)C(=O)OCCCN1CCCN(CCCOC(=O)C2=CC(OC)=C(OC)C(OC)=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 677.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.48 mL 7.38 mL 14.76 mL
5 mM 0.3 mL 1.48 mL 2.95 mL
10 mM 0.15 mL 0.74 mL 1.48 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kawagoe et al (1992) Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantitative study. Naunyn Schmiedebergs Arch.Pharmacol. 345 485 PMID: 1620248

Zhang et al (1991) Dilazep potentation of adenosine-mediated superior mesenteric arterial vasodilation. J.Pharmacol.Exp.Ther. 258 767 PMID: 1890619


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Keywords: adenosines reuptake inhibitors inhibits ENT1 Purine Transporters Pyrimidine Equilibrative Nucleoside Monoamine Neurotransmitter vasodilator Nucleoside Transporters

Citations for Dilazep dihydrochloride

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