JTC 801

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Selective NOP antagonist
Chemical Name: N-(4-Amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)

Biological Activity for JTC 801

JTC 801 is a high affinity, selective NOP receptor antagonist (Ki = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human μ-, κ- and δ-opioid receptors respectively. Exhibits anti-nociceptive effects in acute pain models in vivo. Orally active.

Compound Libraries for JTC 801

JTC 801 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JTC 801

M. Wt 447.96
Formula C26H25N3O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 244218-51-7
PubChem ID 5311339
InChI Key NQLIYKXNAXKMBL-UHFFFAOYSA-N
Smiles Cl.CCC1=CC=C(OCC2=CC=CC=C2C(=O)NC2=CC3=C(N)C=C(C)N=C3C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JTC 801

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.8 100
ethanol 8.96 20

Preparing Stock Solutions for JTC 801

The following data is based on the product molecular weight 447.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.16 mL 22.32 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
10 mM 0.22 mL 1.12 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for JTC 801

Certificate of Analysis / Product Datasheet
Select another batch:

References for JTC 801

References are publications that support the biological activity of the product.

Shinkai et al (2000) 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. J.Med.Chem 43 4667 PMID: 11101358

Yamada et al (2002) Pharmacological profiles of a novel opioid receptor-like1 (ORL1) receptor antagonist, JTC-801. Br.J.Pharmacol. 135 323 PMID: 11815367

Tamai et al (2005) Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist, JTC-801, in rats after spinal nerve injury and inflammation. Eur.J.Pharmacol. 510 223 PMID: 15763246


If you know of a relevant reference for JTC 801, please let us know.

View Related Products by Target

View Related Products by Product Action

View all NOP Receptor Antagonists

Keywords: JTC 801, JTC 801 supplier, Selective, NOP, antagonists, Nociceptin, Receptors, ORL1, OP4, Opioids, JTC801, 2481, Tocris Bioscience

3 Citations for JTC 801

Citations are publications that use Tocris products. Selected citations for JTC 801 include:

Zhang et al (2015) Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder. PLoS One 172 571 PMID: 24666365

Delaney et al (2012) Role of nociceptin/orphanin FQ and NOP receptors in the response to acute and repeated restraint stress in rats. J Neuroendocrinol 24 1527 PMID: 22835008

Mahmoud et al (2010) Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons. Mol Pharmacol 77 804 PMID: 20159949


Do you know of a great paper that uses JTC 801 from Tocris? Please let us know.

Reviews for JTC 801

There are currently no reviews for this product. Be the first to review JTC 801 and earn rewards!

Have you used JTC 801?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.