Nociceptin

Pricing Availability Delivery Time Qty
Cat.No. 0910 - Nociceptin | Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln | CAS No. 170713-75-4
Description: Endogenous NOP agonist
Alternative Names: Orphanin FQ
Datasheet
Citations (11)
Literature

Biological Activity

Endogenous ligand for the NOP opioid receptor (pKi = 8.6). Has no significant activity at μ, δ or κ opioid receptors (pKi < 6).

Technical Data

M. Wt 1809
Formula C79H129N27O22
Sequence FGGFTGARKSARKLANQ
Storage Desiccate at -20°C
CAS Number 170713-75-4
PubChem ID 16131448
InChI Key PULGYDLMFSFVBL-SMFNREODSA-N
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1809. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.55 mL 2.76 mL 5.53 mL
5 mM 0.11 mL 0.55 mL 1.11 mL
10 mM 0.06 mL 0.28 mL 0.55 mL
50 mM 0.01 mL 0.06 mL 0.11 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Guerrini et al (2000) Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A. Peptides 21 923 PMID: 10998526

Henderson and McKnight (1997) The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ. TiPS 18 293 PMID: 9277133

Reinscheid et al (1995) Orphanin FQ: a neuropeptide that activates an opioid like G protein coupled receptor. Science 270 792 PMID: 7481766

Meunier et al (1995) Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 377 532 PMID: 7566152


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Keywords: Nociceptin, supplier, Endogenous, NOP, agonists, Nociceptin, Receptors, ORL1, OP4, Opioid, Orphanin, FQ, NOP, Receptors, NOP, Receptors, Tocris Bioscience

11 Citations for Nociceptin

Citations are publications that use Tocris products. Selected citations for Nociceptin include:

Miranda-Morales et al (2013) Participation of the nociceptin/orphanin FQ receptor in ethanol-mediated locomotor activation and ethanol intake in preweanling rats. Behav Brain Res 245 137 PMID: 23439216

Lee et al (2011) Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors. PLoS One 36 2008 PMID: 21671107

McIlwrath and Westlund (2015) Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats. J Cell Mol Med 21 836 PMID: 25624717

Wang et al (2015) Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors. Psychopharmacology (Berl) 19 2587 PMID: 26153065

Kelly et al (2015) The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours. Neurochem Res 232 305 PMID: 24973897

Farrag et al (2015) Modulation of voltage-gated Ca2+ channels by G protein-coupled receptors in celiac-mesenteric ganglion neurons of septic rats. BMC Complement Altern Med 10 e0125566 PMID: 26017846

Popiolek-Barczyk et al (2014) Minocycline enhances the effectiveness of nociceptin/orphanin FQ during neuropathic pain. Biomed Res Int 2014 762930 PMID: 25276817

Kokkola et al (2005) S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner. BMC Cell Biol 6 21 PMID: 15850493

Kuzmin et al (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol 141 132 PMID: 14662736

McLeod et al (2001) Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors. World J Gastroenterol 132 1175 PMID: 11250866

Giuliani and Maggi (1996) Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide. Br J Pharmacol 118 1567 PMID: 8842416


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