SCH 221510

Pricing Availability   Qty
Description: Potent and selective NOP agonist
Chemical Name: 3-Endo-8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity for SCH 221510

SCH 221510 is a potent and selective nociceptin opioid receptor (NOP) agonist (EC50 values are 12, 693, 683 and 8071 nM, and Ki values are 0.3, 65, 131 and 2854 nM at NOP, μ-, κ- and δ-opioid receptors respectively). Exhibits anxiolytic-like activity at doses that have no effect on overt behaviors such as locomotion in vivo. Orally active.

Compound Libraries for SCH 221510

SCH 221510 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SCH 221510

M. Wt 397.55
Formula C28H31NO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 322473-89-2
PubChem ID 9887077
Smiles OC1(C2=CC=CC=C2)CC3N(C(C5=CC=CC=C5C)C4=C(C)C=CC=C4)C(CC3)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SCH 221510

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.76 100

Preparing Stock Solutions for SCH 221510

The following data is based on the product molecular weight 397.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.58 mL 25.15 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets for SCH 221510

Certificate of Analysis / Product Datasheet
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References for SCH 221510

References are publications that support the biological activity of the product.

Varty et al (2008) The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510). J.Pharmacol.Exp.Ther. 326 672 PMID: 18492950

Lambert (2008) The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential. Nat.Rev.Drug Discov. 7 694 PMID: 18670432

Yang et al (2009) Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety. Bioorg.Med.Chem.Lett. 19 2482 PMID: 19332374

If you know of a relevant reference for SCH 221510, please let us know.

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Keywords: SCH 221510, SCH 221510 supplier, SCH221510, NOP, nociceptin, opioid, receptors, agonists, ORL1, Receptors, 3240, Tocris Bioscience

1 Citation for SCH 221510

Citations are publications that use Tocris products. Selected citations for SCH 221510 include:

Wu & Liu (2018) ORL1 activation mediates a novel ORL1 receptor agonist SCH221510 analgesia in neuropathic pain in rats. J Mol Neurosci 66 10 PMID: 30074175

Do you know of a great paper that uses SCH 221510 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.