Cyprodime hydrochloride

Pricing Availability   Qty
Description: Selective μ antagonist
Chemical Name: 17-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one hydrochloride
Purity: ≥98% (HPLC)
Citations (2)
Literature (2)

Biological Activity for Cyprodime hydrochloride

Cyprodime hydrochloride is a selective μ-opioid receptor antagonist (Ki values are 5.4, 244.6 and 2187 nM for μ-, δ- and κ-opioid receptors respectively). Reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.

Technical Data for Cyprodime hydrochloride

M. Wt 391.93
Formula C22H29NO3.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 2387505-50-0
PubChem ID 71628324
Smiles O=C3C[C@]24C1=C(OC)C=CC=C1C[C@@H](N(CC5CC5)CC4)[C@@](OC)2CC3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cyprodime hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.19 100
ethanol 39.19 100

Preparing Stock Solutions for Cyprodime hydrochloride

The following data is based on the product molecular weight 391.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.76 mL 25.51 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets for Cyprodime hydrochloride

Certificate of Analysis / Product Datasheet
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References for Cyprodime hydrochloride

References are publications that support the biological activity of the product.

Schmidhammer et al (1995) Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime. J.Med.Chem. 38 3071 PMID: 7636870

Marki et al (1999) μ-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPγs binding assays. Eur.J.Pharmacol. 383 209 PMID: 10585536

Henry et al (2001) μ- and δ-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Exp.Neurol. 171 139 PMID: 11520128

If you know of a relevant reference for Cyprodime hydrochloride, please let us know.

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2 Citations for Cyprodime hydrochloride

Citations are publications that use Tocris products. Selected citations for Cyprodime hydrochloride include:

Norris et al (2019) The Bivalent Rewarding and Aversive properties of δ9-tetrahydrocannabinol are Mediated Through Dissociable Opioid Receptor Substrates and Neuronal Modulation Mechanisms in Distinct Striatal Sub-Regions. Sci Rep 9 9760 PMID: 31278333

Lee et al (2012) Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats. J Neurosci 2012 941685 PMID: 22645476

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

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