Cyprodime hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 2601 - Cyprodime hydrochloride | C22H29NO3.HCl | CAS No. 118111-54-9
Description: Selective μ antagonist
Chemical Name: 17-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective μ-opioid receptor antagonist (Ki values are 5.4, 244.6 and 2187 nM for μ-, δ- and κ-opioid receptors respectively). Reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.

Technical Data

M. Wt 391.93
Formula C22H29NO3.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 118111-54-9
PubChem ID 71628324
InChI Key MMOBYZBXXHEAAX-NCBCLDNOSA-N
Smiles O=C3C[C@]24C1=C(OC)C=CC=C1C[C@@H](N(CC5CC5)CC4)[C@@](OC)2CC3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.19 100
ethanol 39.19 100

Preparing Stock Solutions

The following data is based on the product molecular weight 391.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.76 mL 25.51 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Schmidhammer et al (1995) Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime. J.Med.Chem. 38 3071 PMID: 7636870

Marki et al (1999) μ-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPγs binding assays. Eur.J.Pharmacol. 383 209 PMID: 10585536

Henry et al (2001) μ- and δ-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Exp.Neurol. 171 139 PMID: 11520128


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Keywords: Cyprodime hydrochloride, supplier, Selective, μ-opioid, mu-opioid, antagonists, MOP, Receptors, OP3, Mu, Opioid, Receptors, Mu, Opioid, Receptors, Tocris Bioscience

1 Citation for Cyprodime hydrochloride

Citations are publications that use Tocris products. Selected citations for Cyprodime hydrochloride include:

Lee et al (2012) Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats. J Neurosci 2012 941685 PMID: 22645476


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