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Description: Selective μ receptor agonist
Chemical Name: N-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(1S)-1-methyl-2-(3-thienyl)ethyl]urea
Purity: ≥98% (HPLC)
Literature (5)

Biological Activity for PZM21

PZM21 is a selective μ receptor agonist (EC50 = 4.6 nM). PZM21 has been reported to exhibit bias for the Gi signaling pathway over arrestin-3. The compound exhibits 500-fold selectivity for μ over δ receptors and no detectable activity at κ or nociceptin receptors and a panel of 316 other GPCRs. PZM21 induces analgesia in a mouse hot plate assay, but not a tail-flick assay and exhibits no significant conditioned place preference response in in vivo assays. CNS penetrant.

Compound Libraries for PZM21

PZM21 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PZM21

M. Wt 361.5
Formula C19H27N3O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1997387-43-5
PubChem ID 121596705
Smiles C[C@H](NC(NC[C@@H](N(C)C)CC1=CC=C(C=C1)O)=O)CC2=CSC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PZM21

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.15 100
ethanol 36.15 100

Preparing Stock Solutions for PZM21

The following data is based on the product molecular weight 361.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.83 mL 27.66 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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References for PZM21

References are publications that support the biological activity of the product.

Manglik et al (2016) Structure-based discovery of opioid analgesics with reduced side effects. Nature 537 185 PMID: 27533032

Hill et al (2018) The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception. Br.J.Pharmacol. 175 2653 PMID: 29582414

If you know of a relevant reference for PZM21, please let us know.

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Keywords: PZM21, PZM21 supplier, selective, mu, opioid, receptor, agonist, μ, analgesic, brain, penetrant, Mu, Opioid, Receptors, 7218, Tocris Bioscience

Citations for PZM21

Citations are publications that use Tocris products.

Currently there are no citations for PZM21. Do you know of a great paper that uses PZM21 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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