Hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A2, liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G1/S boundary in vitro. Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 495.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.02 mL||10.09 mL||20.17 mL|
|5 mM||0.4 mL||2.02 mL||4.03 mL|
|10 mM||0.2 mL||1.01 mL||2.02 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Hadvary et al (1991) The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase. J.Biol.Chem. 266 2021 PMID: 1899234
Kridel et al (2004) Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res. 64 2070 PMID: 15026345
Enc et al (2008) Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects. Am.J.Physiol.Gastrointest.Liver Physiol. 296 G482 PMID: 19109408
If you know of a relevant reference for Orlistat, please let us know.
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Keywords: Fatty acid synthases inhibits inhibitors pancreatic gastric carboxylester lipases Pancreatic antiobesity antihypercholesterolemic antihypercholesterolaemic activity Synthases Esterases FAS FASN Lipases
2 Citations for Orlistat
Citations are publications that use Tocris products. Selected citations for Orlistat include:
Caiati et al (2012) Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep 2 285 PMID: 22368777
Breunig et al (2010) The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. Front Neurosci 30 8965 PMID: 20592217
Do you know of a great paper that uses Orlistat from Tocris? If so please let us know.