Orlistat

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Cat.No. 3540 - Orlistat | C29H53NO5 | CAS No. 96829-58-2
Description: Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity
Chemical Name: N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A2, liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G1/S boundary in vitro. Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo.

Technical Data

M. Wt 495.73
Formula C29H53NO5
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 96829-58-2
PubChem ID 3034010
InChI Key AHLBNYSZXLDEJQ-FWEHEUNISA-N
Smiles O=C1[C@@H](CCCCCC)[C@H](C[C@@H](O[C@]([C@H](CC(C)C)NC([H])=O)=O)CCCCCCCCCCC)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.57 100
ethanol 49.57 100

Preparing Stock Solutions

The following data is based on the product molecular weight 495.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.09 mL 20.17 mL
5 mM 0.4 mL 2.02 mL 4.03 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Hadvary et al (1991) The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase. J.Biol.Chem. 266 2021 PMID: 1899234

Kridel et al (2004) Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res. 64 2070 PMID: 15026345

Enc et al (2008) Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects. Am.J.Physiol.Gastrointest.Liver Physiol. 296 G482 PMID: 19109408


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View all Lipase Inhibitors

Keywords: Orlistat, Orlistat supplier, Fatty, acid, synthases, inhibits, inhibitors, pancreatic, gastric, carboxylester, lipases, Pancreatic, antiobesity, antihypercholesterolemic, antihypercholesterolaemic, activity, Synthases, Esterases, FAS, FASN, Lipases, Acid, Synthase, 3540, Tocris Bioscience

3 Citations for Orlistat

Citations are publications that use Tocris products. Selected citations for Orlistat include:

Caiati et al (2012) Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep 2 285 PMID: 22368777

Musella (2017) A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum. Sci Rep 7 7363 PMID: 28779174

Breunig et al (2010) The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. Front Neurosci 30 8965 PMID: 20592217


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