GSK 264220A

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Cat.No. 3752 - GSK 264220A | C17H21N3O4S | CAS No. 685506-42-7
Description: Endothelial lipase and lipoprotein lipase inhibitor
Chemical Name: N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Endothelial lipase and lipoprotein lipase inhibitor (IC50 values are 0.13 and 0.10 μM respectively).

Technical Data

M. Wt 363.43
Formula C17H21N3O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 685506-42-7
PubChem ID 2810413
InChI Key LVOVQRPAMXCXTM-UHFFFAOYSA-N
Smiles CC1=C(NC(NC2=CC=CC=C2)=O)C=C(S(N3CCCCC3)(=O)=O)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.34 100
ethanol 3.63 10

Preparing Stock Solutions

The following data is based on the product molecular weight 363.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.76 mL 27.52 mL
5 mM 0.55 mL 2.75 mL 5.5 mL
10 mM 0.28 mL 1.38 mL 2.75 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Keller et al (2008) A high-throughput screen for the endothelial lipase using HDL as substrate. J.Biomol.Screen. 13 468 PMID: 18566479

Goodman et al (2009) Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg.Med.Chem.Letts. 19 27 PMID:


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Keywords: GSK264220A endothelial lipase lipoprotein lipases inhibitors inhibits Lipases

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