GSK 264220A

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Description: Endothelial lipase and lipoprotein lipase inhibitor
Chemical Name: N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for GSK 264220A

GSK 264220A is an endothelial lipase and lipoprotein lipase inhibitor (IC50 values are 0.13 and 0.10 μM respectively).

Technical Data for GSK 264220A

M. Wt 363.43
Formula C17H21N3O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 685506-42-7
PubChem ID 2810413
Smiles CC1=C(NC(NC2=CC=CC=C2)=O)C=C(S(N3CCCCC3)(=O)=O)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSK 264220A

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.34 100
ethanol 3.63 10

Preparing Stock Solutions for GSK 264220A

The following data is based on the product molecular weight 363.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.76 mL 27.52 mL
5 mM 0.55 mL 2.75 mL 5.5 mL
10 mM 0.28 mL 1.38 mL 2.75 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets for GSK 264220A

Certificate of Analysis / Product Datasheet
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References for GSK 264220A

References are publications that support the biological activity of the product.

Keller et al (2008) A high-throughput screen for the endothelial lipase using HDL as substrate. J.Biomol.Screen. 13 468 PMID: 18566479

Goodman et al (2009) Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg.Med.Chem.Letts. 19 27

If you know of a relevant reference for GSK 264220A, please let us know.

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Keywords: GSK 264220A, GSK 264220A supplier, GSK264220A, endothelial, lipase, lipoprotein, lipases, inhibitors, inhibits, Lipases, 3752, Tocris Bioscience

1 Citation for GSK 264220A

Citations are publications that use Tocris products. Selected citations for GSK 264220A include:

Pastor et al (2014) Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. J Lipid Res 55 966 PMID: 24610889

Do you know of a great paper that uses GSK 264220A from Tocris? Please let us know.

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Literature in this Area

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Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.