GSK 264220A

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Cat.No. 3752 - GSK 264220A | C17H21N3O4S | CAS No. 685506-42-7
Description: Endothelial lipase and lipoprotein lipase inhibitor
Chemical Name: N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Endothelial lipase and lipoprotein lipase inhibitor (IC50 values are 0.13 and 0.10 μM respectively).

Technical Data

M. Wt 363.43
Formula C17H21N3O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 685506-42-7
PubChem ID 2810413
InChI Key LVOVQRPAMXCXTM-UHFFFAOYSA-N
Smiles CC1=C(NC(NC2=CC=CC=C2)=O)C=C(S(N3CCCCC3)(=O)=O)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.34 100
ethanol 3.63 10

Preparing Stock Solutions

The following data is based on the product molecular weight 363.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.76 mL 27.52 mL
5 mM 0.55 mL 2.75 mL 5.5 mL
10 mM 0.28 mL 1.38 mL 2.75 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Keller et al (2008) A high-throughput screen for the endothelial lipase using HDL as substrate. J.Biomol.Screen. 13 468 PMID: 18566479

Goodman et al (2009) Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg.Med.Chem.Letts. 19 27


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Keywords: GSK 264220A, GSK 264220A supplier, GSK264220A, endothelial, lipase, lipoprotein, lipases, inhibitors, inhibits, Lipases, 3752, Tocris Bioscience

1 Citation for GSK 264220A

Citations are publications that use Tocris products. Selected citations for GSK 264220A include:

Pastor et al (2014) Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. J Lipid Res 55 966 PMID: 24610889


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