Exonucleases

Exonucleases, also known as restriction enzymes, are a group of esterases that cleave nucleotides from RNA or DNA chains by hydrolyzing the phosphodiester bonds at either the 3' or 5' terminus. Exonucleases can exist individually or as part of a larger complex.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3190 Mirin
Inhibitor of MRN exonuclease activity

Exonucleases, also known as restriction enzymes, are a group of esterases that cleave nucleotides from RNA or DNA chains by hydrolyzing the phosphodiester bonds at either the 3' or 5' terminus. Exonucleases can exist individually, for example RNase D, or as part of a larger complex, for example Mre11 exists in a multimeric complex with Rad50 and Nbs1. Exonucleases are nuclear enzymes and are vital for DNA synthesis, proofreading and repair.

Literature for Exonucleases

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New Product Guide (Spring/Summer 2017)

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  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Exonuclease Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Mre11 Human MRE11A NM_005591 P49959
Mouse Mre11a NM_018736 Q61216
Rat Mre11a NM_022279 Q9JIM0
ERI1 Human ERI1 NM_153332 Q8IV48
Mouse Thex1 NM_026067 Q7TMF2
Rat Thex1 NM_001014143 Q5FVR4
ERI2 Human ERI2 NM_080663 A8K979
ERI3 Human ERI3 NM_024066 O43414
Mouse Prnpip1 NM_080469 Q8C460
EXO1 Human EXO1 NM_006027 Q9UQ84
Mouse Exo1 NM_012012 Q9QZ11
Rat Exo1 NM_001107198 XP_222932
XRN1 Human XRN1 NM_019001 Q8IZH2
Mouse Xrn1 NM_011916 P97789
Rat Xrn1 XM_217233 XP_217233