- Cell Biology
- Product Type
- Research Area
- New Products
- About Tocris
- Contact Us
DNA ligases play an integral role in DNA repair and replication through catalyzing the formation of phosphodiester bonds. Two classes of DNA ligase have been identified: ATP-dependent (EC 22.214.171.124), and NAD+-dependent (EC 126.96.36.199).
DNA ligases play an integral role in DNA repair and replication through catalyzing the formation of phosphodiester bonds. Two types of DNA ligase have been identified: ATP-dependent DNA ligases (EC 188.8.131.52), and NAD+-dependent DNA ligases (EC 184.108.40.206).
The ATP-dependent DNA ligases are divided into four classes: DNA ligase I, II, III and IV. DNA ligase I links Okazaki fragments to form a continuous strand of DNA; DNA ligase II is an alternatively spliced form of DNA ligase III, found only in non-dividing cells; DNA ligase III is involved in base excision repair; and DNA ligase IV is involved in the repair of DNA double-strand breaks by non-homologous end joining (NHEJ).
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.