DNA Ligases

DNA ligases play an integral role in DNA repair and replication through catalyzing the formation of phosphodiester bonds. Two classes of DNA ligase have been identified: ATP-dependent (EC 6.5.1.1), and NAD+-dependent (EC 6.5.1.2).

Products
Background

Inhibitors

Cat. No. Product Name / Activity
3561 L189
DNA ligase I, III and IV inhibitor

DNA ligases play an integral role in DNA repair and replication through catalyzing the formation of phosphodiester bonds. Two types of DNA ligase have been identified: ATP-dependent DNA ligases (EC 6.5.1.1), and NAD+-dependent DNA ligases (EC 6.5.1.2).

The ATP-dependent DNA ligases are divided into four classes: DNA ligase I, II, III and IV. DNA ligase I links Okazaki fragments to form a continuous strand of DNA; DNA ligase II is an alternatively spliced form of DNA ligase III, found only in non-dividing cells; DNA ligase III is involved in base excision repair; and DNA ligase IV is involved in the repair of DNA double-strand breaks by non-homologous end joining (NHEJ).

External sources of pharmacological information for DNA Ligases :