GPR83 is a member of the Class A receptor family of heterotrimeric G protein-coupled receptors and belongs to the NPY peptide receptor family. Formally an orphan receptor, GPR83 is now known to bind PEN, an endogenous neuropeptide.

Literature (3)
Gene Data

GPR83 Agonists

Cat. No. Product Name / Activity
6308 PEN (mouse)
GPR83 agonist

GPR83, encoded by the GPR83 gene, is a member of the Class A orphan receptor family of heterotrimeric G-protein coupled receptors and belongs to the NPY peptide receptor family. Formally an orphan receptor, GPR83 is now known to bind the endogenous proSAAS peptide PEN, an orexigenic neuropeptide.

GPR83 shows high abundance in the brain, particularly in the areas that regulates energy metabolism, including the amygdala, hypothalamus and brainstem. Expression of both GPR83 and PEN has also been identified in peripheral tissues including the kidneys, liver and spleen. GPR83 knockout mice show reduced stress envoked anxiety, delayed spatial learning and are resisitant to obesity when fed a high fat diet, suggesting GPR83 has a role in learning and memory as well as feeding regulation.

PEN binding to GPR83 leads to Gq mediated activation of phospholipase C as well as Gi mediated inhibition of adenylyl cyclase and cAMP production, suggesting GPR83 may regulate intracellular signaling pathways in various ways.

GPR83 is known to interact with other receptors, including GPR171, the receptor for bigLEN, another proSAAS peptide. Colocalization and interaction of their intracellular signaling pathways suggest GPR83 and GPR171 may be functionally coupled in the regulation of feeding and body weight.

External sources of pharmacological information for GPR83 :

Literature for GPR83

Tocris offers the following scientific literature for GPR83 to showcase our products. We invite you to request* your copy today!

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GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Gut Hormones Poster

Gut Hormones Poster

The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.

GPR83 Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
GPR83 Human GPR83 NM_016540 Q9NYM4
Mouse Gpr83 NM_010287 P30731
Rat Gpr83 NM_080411 NP_536336