Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide. Activates phospholipase C (PLC)-mediated signaling cascade in mouse hypothalamus.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in PBS (pH 7.4)|
Preparing Stock Solutions
The following data is based on the product molecular weight 2317.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.43 mL||2.16 mL||4.31 mL|
|5 mM||0.09 mL||0.43 mL||0.86 mL|
|10 mM||0.04 mL||0.22 mL||0.43 mL|
|50 mM||0.01 mL||0.04 mL||0.09 mL|
References are publications that support the products' biological activity.
Gomes et al (2016) Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci.Signal. 9 ra43 PMID: 27117253
If you know of a relevant reference for PEN (mouse), please let us know.
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Keywords: PEN (mouse), supplier, GPR83, agonists, agonism, neuropeptide, JP05, GPR72, glucocorticoid-induced, receptor, pro-SAAS, (221-242), GPR83, GPR83, Tocris Bioscience
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.