CRF2 Receptors

The corticotropin-releasing factor (CRF) 2 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF1. Three functional splice variants have been identified for the mammalian CRF2 receptor; CRF2a, CRF2b and CRF2c.

Products
Background
Literature
Gene Data

Antagonists

Cat No Product Name / Activity
2071 Antisauvagine-30
Potent, selective and competitive CRF2 antagonist
2391 Astressin 2B
Selective CRF2 antagonist
2070 K 41498
Highly selective and potent CRF2 antagonist

Related Targets

    The corticotropin-releasing factor (CRF) 2 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF1. Three functional splice variants have been identified for the mammalian CRF2 receptor; CRF2a, CRF2b and CRF2c. All three splice variants display different tissue distribution but the pharmacological and biological properties remain unchanged.

    The physiological functions of CRF2 receptors are currently unclear but activation of these receptors is known to induce anxiety and hypersensitivity to stress, and increase glucagon and insulin secretion from islet cells. The human gene encoding the CRF2 receptor is localized on chromosome 17 (17q12-q22).

    External sources of pharmacological information for CRF2 Receptors :

    Literature for CRF2 Receptors

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    CRF2 Receptor Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human CRHR2 NM_001883 Q13324
    Mouse Crhr2 NM_009953 Q60748
    Rat Crhr2 NM_022714 P47866