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Rivastigmine tartrate is a cholinesterase inhibitor; inhibits both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50 ranges are 4.3-4760 nM and 16-238 nM respectively). Rivastigmine increases α-secretase activity and directs APP processing to the non-amyloidogenic pathway. Brain penetrant.
Rivastigmine tartrate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 400.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.5 mL||12.49 mL||24.97 mL|
|5 mM||0.5 mL||2.5 mL||4.99 mL|
|10 mM||0.25 mL||1.25 mL||2.5 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
References are publications that support the biological activity of the product.
Groner et al (2007) The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates. Mol.Pharmacol. 71 1610 PMID: 17347320
Luo et al (2006) Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J.Med.Chem. 49 2174 PMID: 16570913
Mehta et al (2012) New acetylcholinesterase inhibitors for Alzheimer's disease. Int.J.Alzheimers Dis PMID: 22216416
Bailey et al (2011) Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One 6 e21954 PMID: 21799757
Brus et al (2014) J.Med.Chem. 57 8167 PMID: 25226236
If you know of a relevant reference for Rivastigmine tartrate, please let us know.
Keywords: Rivastigmine tartrate, Rivastigmine tartrate supplier, acetylcholinesterase, AChE, butyrylcholinesterase, cholinesterase, BChE, inhibitors, inhibits, ChEI, brain, penetrant, ENA713, Rivastigmine, tartrate, alzheimers, APP, amyloid, alpha, secretase, ENA, 713, Cholinesterases, 4440, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Rivastigmine tartrate include:
Budzynska et al (2015) Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice. Curr Alzheimer Res 232 931 PMID: 25189792
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