Donepezil hydrochloride

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Cat.No. 4385 - Donepezil hydrochloride | C24H29NO3.HCl | CAS No. 120011-70-3
Description: Potent AChE inhibitor
Alternative Names: E 2020
Chemical Name: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Potent acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays 1252-fold selectivity for AChE over BuChE (IC50 = 7138 nM for BuChE). Orally active.

Technical Data

M. Wt 415.95
Formula C24H29NO3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 120011-70-3
PubChem ID 5741
Smiles O=C2C(CC3CCN(CC4=CC=CC=C4)CC3)CC1=CC(OC)=C(OC)C=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.16 10
ethanol 4.16 10
water 31.2 75

Preparing Stock Solutions

The following data is based on the product molecular weight 415.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 12.02 mL 24.04 mL
5 mM 0.48 mL 2.4 mL 4.81 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Sugimoto et al (1995) Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. J.Med.Chem. 38 4821 PMID: 7490731

Kryger et al (1999) Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure 7 297 PMID: 10368299

Sugimoto et al (2000) Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors. Curr.Med.Chem. 7 303 PMID: 10637367

If you know of a relevant reference for Donepezil hydrochloride, please let us know.

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Keywords: acetylcholinesterase ache selective potent inhibitors inhibits E2020 E 2020 Cholinesterases

1 Citation for Donepezil hydrochloride

Citations are publications that use Tocris products. Selected citations for Donepezil hydrochloride include:

Morris et al (2015) Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia. Ann Clin Transl Neurol 2 1012 PMID: 26732627

Do you know of a great paper that uses Donepezil hydrochloride from Tocris? If so please let us know.

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