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Potent acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays 1252-fold selectivity for AChE over BuChE (IC50 = 7138 nM for BuChE). Orally active.
Deuterated analog also available.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 415.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.81 mL||24.04 mL||48.08 mL|
|2.5 mM||0.96 mL||4.81 mL||9.62 mL|
|5 mM||0.48 mL||2.4 mL||4.81 mL|
|25 mM||0.1 mL||0.48 mL||0.96 mL|
References are publications that support the biological activity of the product.
Sugimoto et al (1995) Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. J.Med.Chem. 38 4821 PMID: 7490731
Kryger et al (1999) Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure 7 297 PMID: 10368299
Sugimoto et al (2000) Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors. Curr.Med.Chem. 7 303 PMID: 10637367
If you know of a relevant reference for Donepezil hydrochloride, please let us know.
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Keywords: Donepezil hydrochloride, Donepezil hydrochloride supplier, acetylcholinesterase, ache, selective, potent, inhibitors, inhibits, E2020, E, 2020, Cholinesterases, 4385, Tocris Bioscience
2 Citations for Donepezil hydrochloride
Citations are publications that use Tocris products. Selected citations for Donepezil hydrochloride include:
Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788
Morris et al (2015) Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia. Ann Clin Transl Neurol 2 1012 PMID: 26732627
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Literature in this Area
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.