Donepezil hydrochloride

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Cat.No. 4385 - Donepezil hydrochloride | C24H29NO3.HCl | CAS No. 120011-70-3
Description: Potent AChE inhibitor
Alternative Names: E 2020
Chemical Name: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)

Biological Activity

Potent acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays 1252-fold selectivity for AChE over BuChE (IC50 = 7138 nM for BuChE). Orally active.

Deuterated analog also available.

Technical Data

M. Wt 415.95
Formula C24H29NO3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 120011-70-3
PubChem ID 5741
InChI Key XWAIAVWHZJNZQQ-UHFFFAOYSA-N
Smiles O=C2C(CC3CCN(CC4=CC=CC=C4)CC3)CC1=CC(OC)=C(OC)C=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 20.8 50

Preparing Stock Solutions

The following data is based on the product molecular weight 415.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.81 mL 24.04 mL 48.08 mL
2.5 mM 0.96 mL 4.81 mL 9.62 mL
5 mM 0.48 mL 2.4 mL 4.81 mL
25 mM 0.1 mL 0.48 mL 0.96 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Sugimoto et al (1995) Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. J.Med.Chem. 38 4821 PMID: 7490731

Kryger et al (1999) Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure 7 297 PMID: 10368299

Sugimoto et al (2000) Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors. Curr.Med.Chem. 7 303 PMID: 10637367


If you know of a relevant reference for Donepezil hydrochloride, please let us know.

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Keywords: Donepezil hydrochloride, Donepezil hydrochloride supplier, acetylcholinesterase, ache, selective, potent, inhibitors, inhibits, E2020, E, 2020, Cholinesterases, 4385, Tocris Bioscience

2 Citations for Donepezil hydrochloride

Citations are publications that use Tocris products. Selected citations for Donepezil hydrochloride include:

Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788

Morris et al (2015) Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia. Ann Clin Transl Neurol 2 1012 PMID: 26732627


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Literature in this Area

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