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Long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||7.37||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 368.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||13.58 mL||67.88 mL||135.77 mL|
|1 mM||2.72 mL||13.58 mL||27.15 mL|
|2 mM||1.36 mL||6.79 mL||13.58 mL|
|10 mM||0.27 mL||1.36 mL||2.72 mL|
References are publications that support the biological activity of the product.
Arias et al (2004) Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology 46 103 PMID: 14654102
Capsoni et al (2002) Nerve growth factor and galant. ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc.Natl.Acad.Sci.U.S.A. 99 12432 PMID: 12205295
Harvey (1995) The pharmacology of galanthamine and its analogues. Pharmacol.Ther. 68 113 PMID: 8604434
Samochocki et al (2003) Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 305 1024 PMID: 12649296
Sweeney et al (1989) Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice. Pharmacol.Biochem.Behav. 34 129 PMID: 2626444
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Keywords: Galanthamine hydrobromide, Galanthamine hydrobromide supplier, Galanthamine, Galantamine, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Muscarinic, Receptors, Acetylcholine, Nicotinic, nAChR, Cholinesterases, (Non-selective), 0686, Tocris Bioscience
1 Citation for Galanthamine hydrobromide
Citations are publications that use Tocris products. Selected citations for Galanthamine hydrobromide include:
Souza et al (2012) Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome. Sci Rep 1 137 PMID: 22355654
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.