Galanthamine hydrobromide

Pricing Availability Delivery Time Qty
Cat.No. 0686 - Galanthamine hydrobromide | C17H21NO3.HBr | CAS No. 1953-04-4
Description: Cholinesterase inhibitor
Chemical Name: 4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.

Technical Data

M. Wt 368.27
Formula C17H21NO3.HBr
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1953-04-4
PubChem ID 121587
InChI Key QORVDGQLPPAFRS-XPSHAMGMSA-N
Smiles O[C@H]1C=C[C@]([C@]2=C(O4)C(OC)=CC=C2CN(CC3)C)3[C@@H]4C1.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.83 100
water 18.41 50
phosphate buffered saline 9.21 25

Preparing Stock Solutions

The following data is based on the product molecular weight 368.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.58 mL 27.15 mL
5 mM 0.54 mL 2.72 mL 5.43 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Arias et al (2004) Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology 46 103 PMID: 14654102

Capsoni et al (2002) Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc.Natl.Acad.Sci.U.S.A. 99 12432 PMID: 12205295

Harvey (1995) The pharmacology of galanthamine and its analogues. Pharmacol.Ther. 68 113 PMID: 8604434

Samochocki et al (2003) Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 305 1024 PMID: 12649296

Sweeney et al (1989) Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice. Pharmacol.Biochem.Behav. 34 129 PMID: 2626444


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Keywords: Galanthamine Galantamine Cholinesterase inhibitors inhibits AChE Acetylcholinesterase Esterases Muscarinic Receptors Acetylcholine Nicotinic nAChR Cholinesterases

1 Citation for Galanthamine hydrobromide

Citations are publications that use Tocris products. Selected citations for Galanthamine hydrobromide include:

Souza et al (2012) Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome. Sci Rep 1 137 PMID: 22355654


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Neurodegeneration

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