Long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|phosphate buffered saline||9.21||25|
Preparing Stock Solutions
The following data is based on the product molecular weight 368.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.72 mL||13.58 mL||27.15 mL|
|5 mM||0.54 mL||2.72 mL||5.43 mL|
|10 mM||0.27 mL||1.36 mL||2.72 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Arias et al (2004) Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology 46 103 PMID: 14654102
Capsoni et al (2002) Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc.Natl.Acad.Sci.U.S.A. 99 12432 PMID: 12205295
Harvey (1995) The pharmacology of galanthamine and its analogues. Pharmacol.Ther. 68 113 PMID: 8604434
Samochocki et al (2003) Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 305 1024 PMID: 12649296
Sweeney et al (1989) Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice. Pharmacol.Biochem.Behav. 34 129 PMID: 2626444
If you know of a relevant reference for Galanthamine hydrobromide, please let us know.
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Keywords: Galanthamine Galantamine Cholinesterase inhibitors inhibits AChE Acetylcholinesterase Esterases Muscarinic Receptors Acetylcholine Nicotinic nAChR Cholinesterases
1 Citation for Galanthamine hydrobromide
Citations are publications that use Tocris products. Selected citations for Galanthamine hydrobromide include:
Souza et al (2012) Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome. Sci Rep 1 137 PMID: 22355654
Do you know of a great paper that uses Galanthamine hydrobromide from Tocris? If so please let us know.
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