Physostigmine hemisulfate

Pricing Availability   Qty
Description: Cholinesterase inhibitor
Chemical Name: (3aS)-cis-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol methylcarbamate hemisulfate
Purity: ≥98% (HPLC)
Citations (6)
Literature (1)

Biological Activity for Physostigmine hemisulfate

Physostigmine hemisulfate is a cholinesterase inhibitor.

Technical Data for Physostigmine hemisulfate

M. Wt 324.39
Formula C15H21N3O2.½H2SO4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 64-47-1
PubChem ID 21872909
Smiles OS(O)(=O)=O.CNC(=O)OC1=CC=C2N(C)C3N(C)CCC3(C)C2=C1.CNC(=O)OC1=CC=C2N(C)C3N(C)CCC3(C)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Physostigmine hemisulfate

Solvent Max Conc. mg/mL Max Conc. mM
water 32.44 100

Preparing Stock Solutions for Physostigmine hemisulfate

The following data is based on the product molecular weight 324.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.83 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets for Physostigmine hemisulfate

Certificate of Analysis / Product Datasheet
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References for Physostigmine hemisulfate

References are publications that support the biological activity of the product.

Millard and Broomfield (1995) Anticholinesterases: medical applications of neurochemical principles. J.Neurochem 64 1909 PMID: 7722478

Merck Index 12 7540

If you know of a relevant reference for Physostigmine hemisulfate, please let us know.

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View all Cholinesterase Inhibitors

Keywords: Physostigmine hemisulfate, Physostigmine hemisulfate supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, Non-selective, Muscarinics, Cholinesterases, 0622, Tocris Bioscience

6 Citations for Physostigmine hemisulfate

Citations are publications that use Tocris products. Selected citations for Physostigmine hemisulfate include:

Huchzermeyer et al (2013) Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network. J Cereb Blood Flow Metab 33 263 PMID: 23168532

Galow et al (2014) Energy substrates that fuel fast neuronal network oscillations. J Neurosci 8 398 PMID: 25538552

Parent et al (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Proc Natl Acad Sci U S A 9 284 PMID: 26578914

Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. Front Neurosci 112 8124 PMID: 26080439

Do you know of a great paper that uses Physostigmine hemisulfate from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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