Physostigmine hemisulfate

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Cat.No. 0622 - Physostigmine hemisulfate | C15H21N3O2.1/2H2SO4 | CAS No. 64-47-1
Description: Cholinesterase inhibitor
Chemical Name: (3aS)-cis-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol methylcarbamate hemisulfate
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Literature

Biological Activity

Cholinesterase inhibitor.

Technical Data

M. Wt 324.39
Formula C15H21N3O2.1/2H2SO4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 64-47-1
PubChem ID 21872909
InChI Key YYBNDIVPHIWTPK-UHFFFAOYSA-N
Smiles OS(O)(=O)=O.CNC(=O)OC1=CC=C2N(C)C3N(C)CCC3(C)C2=C1.CNC(=O)OC1=CC=C2N(C)C3N(C)CCC3(C)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 32.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 324.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.83 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Millard and Broomfield (1995) Anticholinesterases: medical applications of neurochemical principles. J.Neurochem 64 1909 PMID: 7722478

Merck Index 12 7540 PMID:


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View all Cholinesterase Inhibitors

Keywords: Cholinesterase inhibitors inhibits AChE Acetylcholinesterase Esterases Acetylcholine Nicotinic Receptors nAChR Muscarinic Cholinesterases

4 Citations for Physostigmine hemisulfate

Citations are publications that use Tocris products. Selected citations for Physostigmine hemisulfate include:

Parent et al (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Proc Natl Acad Sci U S A 9 284 PMID: 26578914

Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. Front Neurosci 112 8124 PMID: 26080439

Galow et al (2014) Energy substrates that fuel fast neuronal network oscillations. J Neurosci 8 398 PMID: 25538552

Huchzermeyer et al (2013) Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network. J Cereb Blood Flow Metab 33 263 PMID: 23168532


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Literature in this Area

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Pathways for Physostigmine hemisulfate

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