|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 324.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.08 mL||15.41 mL||30.83 mL|
|5 mM||0.62 mL||3.08 mL||6.17 mL|
|10 mM||0.31 mL||1.54 mL||3.08 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Millard and Broomfield (1995) Anticholinesterases: medical applications of neurochemical principles. J.Neurochem 64 1909 PMID: 7722478
If you know of a relevant reference for Physostigmine hemisulfate, please let us know.
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Keywords: Cholinesterase inhibitors inhibits AChE Acetylcholinesterase Esterases Acetylcholine Nicotinic Receptors nAChR Muscarinic Cholinesterases
4 Citations for Physostigmine hemisulfate
Citations are publications that use Tocris products. Selected citations for Physostigmine hemisulfate include:
Parent et al (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Proc Natl Acad Sci U S A 9 284 PMID: 26578914
Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. Front Neurosci 112 8124 PMID: 26080439
Galow et al (2014) Energy substrates that fuel fast neuronal network oscillations. J Neurosci 8 398 PMID: 25538552
Huchzermeyer et al (2013) Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network. J Cereb Blood Flow Metab 33 263 PMID: 23168532
Do you know of a great paper that uses Physostigmine hemisulfate from Tocris? If so please let us know.
Literature in this Area
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.