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Description: Natural cannabinoid; GPR55 antagonist, weak CB1 antagonist, CB2 inverse agonist and AMT inhibitor
Alternative Names: CBD
Chemical Name: 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
Purity: ≥99% (HPLC)
Citations (5)
Literature (1)

Biological Activity for (-)-Cannabidiol

(-)-Cannabidiol is a non-psychotropic constituent of cannabis that is anticonvulsive, antihyperalgesic and neuroprotective in vivo. GPR55 and weak CB1 antagonist (IC50 values are 0.445 and 3.35 μM), CB2 receptor inverse agonist and inhibitor of anandamide uptake (IC50 = 27.5 μM). Also inhibits FABPs and a weak agonist at TRP vanilloid receptors (EC50 = 3.5 μM).

Technical Data for (-)-Cannabidiol

M. Wt 314.47
Formula C21H30O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 13956-29-1
PubChem ID 12302390
Smiles CCCCCC1=CC(O)=C([C@H]2C=C(C)CC[C@H]2C(C)=C)C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (-)-Cannabidiol

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 23.59 75
DMSO 23.59 75

Preparing Stock Solutions for (-)-Cannabidiol

The following data is based on the product molecular weight 314.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 4.24 mL 21.2 mL 42.4 mL
3.75 mM 0.85 mL 4.24 mL 8.48 mL
7.5 mM 0.42 mL 2.12 mL 4.24 mL
37.5 mM 0.08 mL 0.42 mL 0.85 mL

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Product Datasheets for (-)-Cannabidiol

Certificate of Analysis / Product Datasheet
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References for (-)-Cannabidiol

References are publications that support the biological activity of the product.

Costa et al (2004) Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation. Br.J.Pharmacol. 143 247 PMID: 15313881

Petitet et al (1998) Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of Δ9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. Life Sci. 63 PL1 PMID: 9667767

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302

Thomas et al (2007) Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br.J.Pharmacol. 150 613 PMID: 17245363

Deutsch (2016) A personal retrospective: Elevating Anandamide (AEA) by targeting fatty acid amide hydrolase (FAAH) and the fatty acid binding proteins (FABPs). Front.Pharmacol. 7 370 PMID: 27790143

If you know of a relevant reference for (-)-Cannabidiol, please let us know.

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5 Citations for (-)-Cannabidiol

Citations are publications that use Tocris products. Selected citations for (-)-Cannabidiol include:

Rodríguez-Muñoz et al (2018) Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain 11 51 PMID: 30223868

Panja et al (2019) Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. Neuropathol Appl Neurobiol 45 141 PMID: 29679372

Whyte et al (2009) The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. PLoS One 106 16511 PMID: 19805329

Hamtiaux et al (2011) Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. PLoS One 6 e26823 PMID: 22046372

Do you know of a great paper that uses (-)-Cannabidiol from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.