Bombesin Receptors

Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).

Products
Background
Gene Data

Agonists

Cat No Product Name / Activity
5600 BA 1
Potent BRS-3 agonist; also NMBR and GRPR agonist
2716 BIM 187
Bombesin/GRP receptor agonist
1149 Bombesin
Involved in gastrointestinal tract function
1789 GRP (human)
Endogenous GRP receptor agonist
1788 GRP (porcine)
Endogenous GRP receptor agonist

Antagonists

Cat No Product Name / Activity
2717 BIM 189
Bombesin antagonist
3237 BIM 23042
Selective neuromedin B receptor antagonist (NMB-R, BB1)
1913 [D-Phe12]-Bombesin
Bombesin receptor antagonist
3422 [D-Phe12,Leu14]-Bombesin
Bombesin receptor antagonist
5599 ML 18
BRS-3 antagonist; also GRPR agonist
2602 PD 176252
GRP (BB2) and NMB (BB1) receptor antagonist

Other

Cat No Product Name / Activity
1893 Alytesin
Amphibian bombesin-like peptide
1916 Litorin
Amphibian bombesin-like peptide
1908 Neuromedin B (porcine)
Mammalian bombesin-like peptide

Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor (BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor).

The receptors are Gq/11-coupled and are involved in the regulation of many biological functions including sensory transmission, thermoregulation, feeding and pituitary, gastric and pancreatic secretion. They may also be involved in tissue development, proliferation and differentiation.

External sources of pharmacological information for Bombesin Receptors :

Bombesin Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
BB1 Human NMBR NM_002511 P28336
Mouse Nmbr NM_008703 O54799
Rat Nmbr NM_012799 P24053
BB2 Human GRPR NM_005314 P30550
Mouse Grpr NM_008177 P21729
Rat Grpr NM_012706 P52500
bb3 Human BRS3 NM_001727 P32247
Mouse Brs3 NM_009766 O54798
Rat Brs3 NM_152845 Q8K418