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Bombesin Receptors

Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).

Products
Background
Literature (3)
Gene Data

Bombesin Receptor Agonists
Cat. No. Product Name / Activity
1789 GRP (human)
Endogenous GRP receptor agonist

Bombesin Receptor Antagonists
Cat. No. Product Name / Activity
2602 PD 176252
GRP (BB2) and NMB (BB1) receptor antagonist

Other
Cat. No. Product Name / Activity
1908 Neuromedin B (porcine)
Mammalian bombesin-like peptide

Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). There are three subtypes of the bombesin receptor. BB1 was previously known as the NMB receptor while BB2 was previously known as the GRP receptor. BB3 is designated an orphan receptor, however it has been shown to respond to NMB peptides, albeit at a lower potentcy than BB1.

The receptors are Gq/11-coupled and are involved in the regulation of many biological functions including sensory transmission, thermoregulation, feeding and pituitary, gastric and pancreatic secretion. They may also be involved in tissue development, proliferation and differentiation.

External sources of pharmacological information for Bombesin Receptors :

Literature for Bombesin Receptors

Tocris offers the following scientific literature for Bombesin Receptors to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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Peptide Hormone Receptors Product Listing

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Bombesin Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
BB1 Human NMBR NM_002511 P28336
Mouse Nmbr NM_008703 O54799
Rat Nmbr NM_012799 P24053
BB2 Human GRPR NM_005314 P30550
Mouse Grpr NM_008177 P21729
Rat Grpr NM_012706 P52500
bb3 Human BRS3 NM_001727 P32247
Mouse Brs3 NM_009766 O54798
Rat Brs3 NM_152845 Q8K418