Apelin Receptors

Apelin-36, apelin-13 and [Pyr1]-apelin-13 are the predominant endogenous ligands for the apelin receptor (APJ) receptor. The APJ receptor and apelin peptides act as mediators of cardiovascular function, fluid homeostasis and adipocyte endocrine secretion.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
2420 [Pyr1]-Apelin-13
Potent peptide agonist for APJ receptor
3007 Apelin-17 (human, bovine)
Endogenous APJ receptor agonist
2426 Apelin-36 (human)
Endogenous APJ receptor agonist
2427 Apelin-36 (rat, mouse)
Endogenous APJ receptor agonist
6293 ELA-14 (human)
Potent apelin (APJ) receptor agonist
6291 ELA-32 (human)
Potent, high affinity apelin receptor agonist; stimulates angiogenesis
5966 ML 233
Non-peptide apelin receptor agonist

Antagonists

Cat No Product Name / Activity
4748 ML 221
Apelin receptor (APJ) antagonist
5992 MM 54
Potent apelin receptor antagonist

Other

Cat No Product Name / Activity
6292 ELARR>GG
Negative control for ELA-32 (Cat.No.6291).
6294 ELA-14 negative control
Negative control for ELA-14 (Cat.No.6293).

Apelin-36, apelin-13 and [Pyr1]-apelin-13 are the predominant endogenous ligands for the apelin receptor (APJ receptor), a G-protein-coupled receptor with considerable sequence homology to the angiotensin (AT1) receptor. The APJ receptor and apelin peptides act as mediators of cardiovascular function, fluid homeostasis and adipocyte endocrine secretion.

External sources of pharmacological information for Apelin Receptors :

Literature for Apelin Receptors

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Apelin Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human APLNR NM_005161 P35414
Mouse Aplnr NM_011784 Q9WV08
Rat Aplnr NM_031349 Q9JHG3