[Pyr1]-Apelin-13

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Cat.No. 2420 - [Pyr1]-Apelin-13 | Glp-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe | CAS No. 217082-60-5
Description: Potent peptide agonist for APJ receptor
Alternative Names: [pGlu1]-Apelin-13
Datasheet
Citations
Literature

Biological Activity

Highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC50 = 0.37 nM) that displays potent vascular effects in vivo.

Technical Data

M. Wt 1533.81
Formula C69H108N22O16S
Sequence XRPRLSHKGPMPF

(Modifications: X = Glp)

Storage Desiccate at -20°C
CAS Number 217082-60-5
PubChem ID 25085173
InChI Key GGMAXEWLXWJGSF-PEWBXTNBSA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1533.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.65 mL 3.26 mL 6.52 mL
5 mM 0.13 mL 0.65 mL 1.3 mL
10 mM 0.07 mL 0.33 mL 0.65 mL
50 mM 0.01 mL 0.07 mL 0.13 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Katugampola et al (2001) [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br.J.Pharmacol. 132 1255 PMID: 11250876

Kagiyama et al (2005) Central and peripheral cardiovascular actions of apelin in conscious rats. Regul.Pept. 125 55 PMID: 15582714

Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251 471 PMID:

Kleinz et al (2005) Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 107 198 PMID: 15907343


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Keywords: Potent peptide agonists APJ Receptors Apelin adipokines [pGlu1]-Apelin-13 Apelin Receptors

Citations for [Pyr1]-Apelin-13

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Literature in this Area

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Pathways for [Pyr1]-Apelin-13

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