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Highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC50 = 0.37 nM) that displays potent vascular effects in vivo.
(Modifications: X = Glp)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Katugampola et al (2001) [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br.J.Pharmacol. 132 1255 PMID: 11250876
Kagiyama et al (2005) Central and peripheral cardiovascular actions of apelin in conscious rats. Regul.Pept. 125 55 PMID: 15582714
Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251 471
Kleinz et al (2005) Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 107 198 PMID: 15907343
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Keywords: [Pyr1]-Apelin-13, [Pyr1]-Apelin-13 supplier, Potent, peptide, agonists, APJ, Receptors, Apelin, adipokines, [pGlu1]-Apelin-13, 2420, Tocris Bioscience
2 Citations for [Pyr1]-Apelin-13
Citations are publications that use Tocris products. Selected citations for [Pyr1]-Apelin-13 include:
Hall et al (2017) Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth. Cancer Lett 386 179 PMID: 27894959
Li (2018) Apelin modulates murine gastric vagal afferent mechanosensitivity. Physiol Behav 194 466 PMID: 29964068
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