[Pyr1]-Apelin-13

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Cat.No. 2420 - [Pyr1]-Apelin-13 | Glp-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe | CAS No. 217082-60-5
Description: Potent peptide agonist for APJ receptor
Alternative Names: [pGlu1]-Apelin-13
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC50 = 0.37 nM) that displays potent vascular effects in vivo.

Technical Data

M. Wt 1533.81
Formula C69H108N22O16S
Sequence XRPRLSHKGPMPF

(Modifications: X = Glp)

Storage Desiccate at -20°C
CAS Number 217082-60-5
PubChem ID 25085173
InChI Key GGMAXEWLXWJGSF-PEWBXTNBSA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Katugampola et al (2001) [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br.J.Pharmacol. 132 1255 PMID: 11250876

Kagiyama et al (2005) Central and peripheral cardiovascular actions of apelin in conscious rats. Regul.Pept. 125 55 PMID: 15582714

Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251 471

Kleinz et al (2005) Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 107 198 PMID: 15907343


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View all Apelin Receptor Agonists

Keywords: [Pyr1]-Apelin-13, [Pyr1]-Apelin-13 supplier, Potent, peptide, agonists, APJ, Receptors, Apelin, adipokines, [pGlu1]-Apelin-13, 2420, Tocris Bioscience

1 Citation for [Pyr1]-Apelin-13

Citations are publications that use Tocris products. Selected citations for [Pyr1]-Apelin-13 include:

Li (2018) Apelin modulates murine gastric vagal afferent mechanosensitivity. Physiol Behav 194 466 PMID: 29964068


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