MM 54

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Cat.No. 5992 - MM 54 | Cys-Arg-Pro-Arg-Leu-Cys-Lys-His-Cys-Arg-Pro-Arg-Leu-Cys | CAS No. 1313027-43-8
Description: Potent apelin receptor antagonist
Datasheet
Citations
Literature

Biological Activity

Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells.

Technical Data

M. Wt 1737.15
Formula C70H121N29O15S4
Sequence CRPRLCKHCRPRLC

(Modifications: Disulfide bridge: 1-6,9-14)

Storage Store at -20°C
CAS Number 1313027-43-8
PubChem ID 122705991
InChI Key BMJYNYGARUVBJU-CSRTWURCSA-N
Smiles [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1737.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.58 mL 2.88 mL 5.76 mL
5 mM 0.12 mL 0.58 mL 1.15 mL
10 mM 0.06 mL 0.29 mL 0.58 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Macaluso et al (2011) Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem 6 1017 PMID: 21560248


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Keywords: MM 54, supplier, MM54, potent, apelin, receptors, antagonists, antagonism, Apelin, Receptors, Tocris Bioscience

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Literature in this Area

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Pathways for MM 54

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