MM 54

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Description: Potent apelin antagonist
Purity: ≥95% (HPLC)

Biological Activity for MM 54

MM 54 is a potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.

Technical Data for MM 54

M. Wt 1737.15
Formula C70H121N29O15S4

(Modifications: Disulfide bridges: 1-6, 9-14)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1313027-43-8
PubChem ID 122705991
Smiles [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MM 54

Solubility Soluble to 2 mg/ml in water

Product Datasheets for MM 54

Certificate of Analysis / Product Datasheet
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References for MM 54

References are publications that support the biological activity of the product.

Macaluso et al (2011) Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem 6 1017 PMID: 21560248

Harford-Wright et al (2017) Pharmacological targeting of apelin impairs glioblastoma growth. Brain 140 2939 PMID: 29053791

If you know of a relevant reference for MM 54, please let us know.

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Citations for MM 54

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