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Submit ReviewMM 54
Description: Potent apelin antagonist
Purity: ≥95% (HPLC)
Biological Activity for MM 54
MM 54 is a potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.
Technical Data for MM 54
| M. Wt | 1737.15 |
| Formula | C70H121N29O15S4 |
| Sequence |
CRPRLCKHCRPRLC (Modifications: Disulfide bridges: 1-6, 9-14) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1313027-43-8 |
| PubChem ID | 122705991 |
| InChI Key | BMJYNYGARUVBJU-CSRTWURCSA-N |
| Smiles | [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MM 54
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for MM 54
References for MM 54
References are publications that support the biological activity of the product.
Macaluso et al (2011) Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem 6 1017 PMID: 21560248
Harford-Wright et al (2017) Pharmacological targeting of apelin impairs glioblastoma growth. Brain 140 2939 PMID: 29053791
If you know of a relevant reference for MM 54, please let us know.
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Keywords: MM 54, MM 54 supplier, MM54, potent, apelin, receptors, antagonists, antagonism, Apelin, Receptors, 5992, Tocris Bioscience
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