ML 233

Pricing Availability Delivery Time Qty
Cat.No. 5966 - ML 233 | C19H21NO4S
Description: Non-peptide apelin receptor agonist
Chemical Name: (E)-4-Methyl-5-(((phenylsulfonyl)oxy)imino)-[1,1'-bi(cyclohexane)]-3,6-dien-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Non-peptide apelin receptor agonist (EC50 = 3.7 μM); exhibits >21-fold selectivity over the closely related angiotensin 1 receptor (EC50 = >79 μM).

Technical Data

M. Wt 359.44
Formula C19H21NO4S
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 60138111
InChI Key RSMZOLWJZGIWOV-CZIZESTLSA-N
Smiles CC(/C(C=C1C2CCCCC2)=N/OS(C3=CC=CC=C3)(=O)=O)=CC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.97 50
ethanol 3.59 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 359.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.91 mL 27.82 mL
5 mM 0.56 mL 2.78 mL 5.56 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Yang et al (2015) Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. Trends Pharmacol Sci. 36 560 PMID: 26143239

Khan et al (2011) Functional agonists of the apelin (APJ) receptor. Probe Reports from the NIH Molecular Libraries Program PMID: 22834038


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Literature in this Area

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Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pathways for ML 233

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