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Non-peptide apelin receptor agonist (EC50 = 3.7 μM); exhibits >21-fold selectivity over the closely related angiotensin 1 receptor (EC50 = >79 μM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 359.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.56 mL||27.82 mL||55.64 mL|
|2.5 mM||1.11 mL||5.56 mL||11.13 mL|
|5 mM||0.56 mL||2.78 mL||5.56 mL|
|25 mM||0.11 mL||0.56 mL||1.11 mL|
References are publications that support the biological activity of the product.
Yang et al (2015) Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. Trends Pharmacol Sci. 36 560 PMID: 26143239
Khan et al (2011) Functional agonists of the apelin (APJ) receptor. Probe Reports from the NIH Molecular Libraries Program PMID: 22834038
If you know of a relevant reference for ML 233, please let us know.
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Keywords: ML 233, ML 233 supplier, ML233, Potent, non, peptide, agonists, APJ, Receptors, Apelin, adipokines, 5966, Tocris Bioscience
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