ML 233

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Cat.No. 5966 - ML 233 | C19H21NO4S
Description: Non-peptide apelin receptor agonist
Chemical Name: (E)-4-Methyl-5-(((phenylsulfonyl)oxy)imino)-[1,1'-bi(cyclohexane)]-3,6-dien-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Non-peptide apelin receptor agonist (EC50 = 3.7 μM); exhibits >21-fold selectivity over the closely related angiotensin 1 receptor (EC50 = >79 μM).

Technical Data

M. Wt 359.44
Formula C19H21NO4S
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 60138111
InChI Key RSMZOLWJZGIWOV-CZIZESTLSA-N
Smiles CC(/C(C=C1C2CCCCC2)=N/OS(C3=CC=CC=C3)(=O)=O)=CC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.97 50

Preparing Stock Solutions

The following data is based on the product molecular weight 359.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.56 mL 27.82 mL 55.64 mL
2.5 mM 1.11 mL 5.56 mL 11.13 mL
5 mM 0.56 mL 2.78 mL 5.56 mL
25 mM 0.11 mL 0.56 mL 1.11 mL

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References

References are publications that support the biological activity of the product.

Yang et al (2015) Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. Trends Pharmacol Sci. 36 560 PMID: 26143239

Khan et al (2011) Functional agonists of the apelin (APJ) receptor. Probe Reports from the NIH Molecular Libraries Program PMID: 22834038


If you know of a relevant reference for ML 233, please let us know.

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Citations for ML 233

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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