Dynamin inhibitory peptide, myristoylated

Cat. No. 1775

Dynamin inhibitory peptide, myristoylated Myr-Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro-NH2

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Biological Activity

Cell-permeable version of dynamin inhibitory peptide (Cat. No. 1774), an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Reduces NMDA receptor internalization.

Technical Data

M.Wt:
1330.64
Formula:
C61H107N19O14
Sequence:
QVPSRPNRAP

(Modifications: Gln-1 = Myr-Gln, Pro-10 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
251634-22-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302. PMID: 12646920.

Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972. PMID: 11050117.

Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419. PMID: 9148966.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide, myristoylated include:

Preta et al (2015) Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes. FASEB J 29 1516. PMID: 25550455.

Do you know of a great paper that uses Dynamin inhibitory peptide, myristoylated from Tocris? If so please let us know.

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Keywords: Dynamin inhibitory peptide, myristoylated, supplier, Cell-permeable, dynamin, inhibitors, inhibits, Dynamin, Epac, GTPases, Mitosis, Tocris Bioscience, GTPase Inhibitor products

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