Dynamin inhibitory peptide, myristoylated
Cat. No. 1775
Biological ActivityCell-permeable version of dynamin inhibitory peptide (Cat. No. 1774), an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Reduces NMDA receptor internalization.
(Modifications: Gln-1 = Myr-Gln, Pro-10 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302. PMID: 12646920.
Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972. PMID: 11050117.
Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419. PMID: 9148966.
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Citations are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide, myristoylated include:
Preta et al (2015) Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes. FASEB J 29 1516. PMID: 25550455.
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Keywords: Dynamin inhibitory peptide, myristoylated, supplier, Cell-permeable, dynamin, inhibitors, inhibits, Dynamin, Epac, GTPases, Mitosis, Tocris Bioscience, GTPase Inhibitor products
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October 30 - November 3, 2016
Boston, MA, USA