Dynamin inhibitory peptide, myristoylated (control)
Control peptide version of dynamin inhibitory peptide, myristoylated (Cat. No. 1775), an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. In contrast to dynamin inhibitory peptide, has no significant effect on GABAA receptor-mediated miniature IPSPs.
(Modifications: Gln-1 = Myr-Gln, Arg-10 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 0.67 mg/ml in 30% acetonitrile / water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1330.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.75 mL||3.76 mL||7.52 mL|
|5 mM||0.15 mL||0.75 mL||1.5 mL|
|10 mM||0.08 mL||0.38 mL||0.75 mL|
|50 mM||0.02 mL||0.08 mL||0.15 mL|
References are publications that support the products' biological activity.
Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419 PMID: 9148966
Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972 PMID: 11050117
Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302 PMID: 12646920
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Keywords: Dynamin inhibitory peptide, myristoylated (control), supplier, 1775, Mitosis, Dynamin, Epac, GTPases, GTPase, Mitosis, GTPase, Tocris Bioscience
1 Citation for Dynamin inhibitory peptide, myristoylated (control)
Citations are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide, myristoylated (control) include:
Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. J Neuroinflammation 10 e0131430 PMID: 26102354
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