Dynamin inhibitory peptide, myristoylated (control)

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Cat.No. 1776 - Dynamin inhibitory peptide, myristoylated (control) | Myr-Gln-Pro-Pro-Ala-Ser-Asn-Pro-Arg-Val-Arg-NH2
Description: Control peptide version of dynamin inhibitory peptide, myristoylated (Cat. No. 1775)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Control peptide version of dynamin inhibitory peptide, myristoylated, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. In contrast to dynamin inhibitory peptide, has no significant effect on GABAA receptor-mediated miniature IPSPs.

Active Analog also available.

Technical Data

M. Wt 1330.64
Formula C61H107N19O14
Sequence QPPASNPRVR

(Modifications: Gln-1 = Myr-Gln, Arg-10 = C-terminal amide)

Storage Desiccate at -20°C
PubChem ID 90488709
InChI Key LRWOEJTUKITZIW-ZUSDHBTASA-N
Smiles [H]N([C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)C(=O)CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 0.67 mg/ml in 30% acetonitrile / water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419 PMID: 9148966

Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972 PMID: 11050117

Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302 PMID: 12646920


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Keywords: Dynamin inhibitory peptide, myristoylated (control), Dynamin inhibitory peptide, myristoylated (control) supplier, 1775, Mitosis, Dynamin, Epac, GTPases, 1776, Tocris Bioscience

2 Citations for Dynamin inhibitory peptide, myristoylated (control)

Citations are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide, myristoylated (control) include:

Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. J Neuroinflammation 10 e0131430 PMID: 26102354

Westmark et al (2010) Pin1 and PKMzeta sequentially control dendritic protein synthesis. Sci Signal 3 ra18 PMID: 20215645


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Literature in this Area

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