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Submit ReviewDynamin inhibitory peptide
Description: Dynamin inhibitor
Alternative Names: P4
Purity: ≥95% (HPLC)
Biological Activity for Dynamin inhibitory peptide
Dynamin inhibitory peptide is a peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors.
Cell-permeable version also available.
Technical Data for Dynamin inhibitory peptide
| M. Wt | 1121.26 |
| Formula | C47H80N18O14 |
| Sequence | QVPSRPNRAP |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 251634-21-6 |
| PubChem ID | 90488708 |
| InChI Key | LHQOQXYEPUSHJL-LNIRUYPRSA-N |
| Smiles | [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Dynamin inhibitory peptide
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References for Dynamin inhibitory peptide
References are publications that support the biological activity of the product.
Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419 PMID: 9148966
Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972 PMID: 11050117
Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302 PMID: 12646920
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Keywords: Dynamin inhibitory peptide, Dynamin inhibitory peptide supplier, Dynamin, inhibitors, inhibits, Mitosis, Epac, GTPases, P4, 1774, Tocris Bioscience
13 Citations for Dynamin inhibitory peptide
Citations are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide include:
Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. J Neurosci 10 e0131430 PMID: 26102354
Graziane et al (2009) DA D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism. J Neurosci 284 8329 PMID: 19179335
Zhu et al (2012) Inflammation-induced shift in spinal GABA(A) signaling is associated with a tyrosine kinase-dependent increase in GABA(A) current density in nociceptive afferents. J Neurophysiol 108 2581 PMID: 22914654
Chamma et al (2013) Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons. J Neurosci 33 15488 PMID: 24068817
Glebov et al (2015) Clathrin-independent trafficking of AMPA receptors. J Biol Chem 35 4830 PMID: 25810514
Cuitino et al (2010) Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons. PLoS One 30 8411 PMID: 20573888
Yuen et al (2014) Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons. J Biol Chem 289 25177 PMID: 25056951
Chiang et al (2014) Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles. Nat Commun 5 3356 PMID: 24561832
Pleil et al (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci 18 545 PMID: 25751534
Jiang et al (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism. J Neurosci 26 4318 PMID: 16624952
Xia et al (2007) Activity-dependent synaptic plasticity in retinal ganglion cells. J Neurosci 27 12221 PMID: 17989288
Dewerchin et al (2008) Surface-expressed viral proteins in feline infectious peritonitis virus-infected monocytes are internalized through a clathrin- and caveolae-independent pathway. J Gen Virol 89 2731 PMID: 18931069
Grueter et al (2008) In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression. J Neurosci 28 9261 PMID: 18784306
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