Dynamin inhibitory peptide

Pricing Availability Delivery Time Qty
Cat.No. 1774 - Dynamin inhibitory peptide | Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro | CAS No. 251634-21-6
Description: Dynamin inhibitor
Alternative Names: P4
Datasheet
Citations (8)
Literature

Biological Activity

Peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors. Cell-permeable version also available (Cat. No. 1775).

Technical Data

M. Wt 1121.26
Formula C47H80N18O14
Sequence QVPSRPNRAP
Storage Desiccate at -20°C
CAS Number 251634-21-6
PubChem ID 90488708
InChI Key LHQOQXYEPUSHJL-LNIRUYPRSA-N
Smiles [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1121.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.89 mL 4.46 mL 8.92 mL
5 mM 0.18 mL 0.89 mL 1.78 mL
10 mM 0.09 mL 0.45 mL 0.89 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419 PMID: 9148966

Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972 PMID: 11050117

Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302 PMID: 12646920


If you know of a relevant reference for Dynamin inhibitory peptide, please let us know.

View Related Products by Target

View Related Products by Product Action

View all GTPase Inhibitors

Keywords: Dynamin inhibitory peptide, supplier, Dynamin, inhibitors, inhibits, Mitosis, Epac, GTPases, P4, GTPase, Tocris Bioscience

8 Citations for Dynamin inhibitory peptide

Citations are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide include:

Cuitino et al (2010) Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons. PLoS One 30 8411 PMID: 20573888

Graziane et al (2009) Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism. J Neurosci 284 8329 PMID: 19179335

Dewerchin et al (2008) Surface-expressed viral proteins in feline infectious peritonitis virus-infected monocytes are internalized through a clathrin- and caveolae-independent pathway. J Gen Virol 89 2731 PMID: 18931069

Xia et al (2007) Activity-dependent synaptic plasticity in retinal ganglion cells. J Neurosci 27 12221 PMID: 17989288

Pleil et al (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci 18 545 PMID: 25751534

Glebov et al (2015) Clathrin-independent trafficking of AMPA receptors. J Biol Chem 35 4830 PMID: 25810514

Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. J Neurosci 10 e0131430 PMID: 26102354

Chiang et al (2014) Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles. Nat Commun 5 3356 PMID: 24561832


Do you know of a great paper that uses Dynamin inhibitory peptide from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Dynamin inhibitory peptide

Protocols

TODO: Add Protocols