RBC8

Cat. No. 5411

RBC8 C25H20N4O3 [361185-42-4]

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Chemical Name: 6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)pyrano[2,3-c]pyrazole-5-carbonitrile

Biological Activity

RalA and RalB GTPase inhibitor (EC50 ~3.5 μM). Inhibits the binding of Ral to RaLBP1. Exhibits no detectable inhibition of Ras or RhoA activity. Suppresses growth of xenograft tumors in mice. Cell permeable.

Technical Data

M.Wt:
424.45
Formula:
C25H20N4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
361185-42-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Yan et al (2014) Discovery and characterization of small molecules that target the GTPase Ral. Nature 515 443. PMID: 25219851.

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Keywords: RBC8, supplier, RalA, RalB, ras, like, GTPase, inhibitors, inhibits, antitumour, antitumor, Tocris Bioscience, GTPase Inhibitor products

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