Cat. No. 5411

RBC8 C25H20N4O3 [361185-42-4]

Price and Availability

For RBC8 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)pyrano[2,3-c]pyrazole-5-carbonitrile

Biological Activity

RalA and RalB GTPase inhibitor (EC50 ~3.5 μM). Inhibits the binding of Ral to RaLBP1. Exhibits no detectable inhibition of Ras or RhoA activity. Suppresses growth of xenograft tumors in mice. Cell permeable.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yan et al (2014) Discovery and characterization of small molecules that target the GTPase Ral. Nature 515 443. PMID: 25219851.

If you know of a relevant reference for RBC8 please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses RBC8 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: RBC8, supplier, RalA, RalB, ras, like, GTPase, inhibitors, inhibits, antitumour, antitumor, Tocris Bioscience, GTPase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

Spring/Summer 2017

New Product Guide (Spring/Summer 2017)

Our New Product guide highlights over 130 new products added in the first half of 2017. View PDF today.

divider line

New Products in this Area

NAV 2729

Selective ARF6 inhibitor

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.