Wnt-C59

Cat. No. 5148

Wnt-C59 C25H21N3O [1243243-89-1]

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Chemical Name: 4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide

Biological Activity

Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/β-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat. No. 4423). Cell permeable and orally bioavailable.

Technical Data

M.Wt:
379.45
Formula:
C25H21N3O
Solubility:
Soluble to 20 mM in DMSO and to 20 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
1243243-89-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Burridge et al (2014) Chemically defined generation of human cardiomyocytes. Nat.Methods 11 855. PMID: 24930130.

Proffitt et al (2013) Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 73 502. PMID: 23188502.

Wend et al (2013) WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer. EMBO Mol.Med. 5 264. PMID: 23307470.

Youssef et al (2012) Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nat. Cell Biol. 14 1282. PMID: 23178882.

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Keywords: Wnt-C59, supplier, Highly, potent, porcn, inhibitors, inhibits, membrane-bound, O-acyltransferase, MBOAT, Wnt, signaling, pathways, WntC59, Tocris Bioscience, PORCN Inhibitor products

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