Salirasib

Cat. No. 4989

Salirasib C22H30O2S [162520-00-5]

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Chemical Name: 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic acid

Biological Activity

Inhibitor of active Ras proteins. Displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also facilitates Ras degradation. Shown to induce autophagy in several human cancer cell lines.

Technical Data

M.Wt:
358.54
Formula:
C22H30O2S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
162520-00-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Faigenbaum et al (2013) Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib. Oncotarget 4 316. PMID: 23530112.

Schmukler et al (2013) Ras inhibition enhances autophagy, which partially protects cells from death. Oncotarget 4 142. PMID: 23370967.

Haklai et al (1998) Dislodgement and accelerated degradation of Ras. Biochemistry 37 1306. PMID: 9477957.

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Citations are publications that use Tocris products. Selected citations for Salirasib include:

Lee et al (2015) A systems-biological study on the identification of safe and effective molecular targets for the reduction of ultraviolet B-induced skin pigmentation. J Virol 5 10305. PMID: 25980672.

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Keywords: Salirasib, supplier, Ras, inhibitors, inhibits, induces, autophagy, Tocris Bioscience, GTPase Inhibitor products

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