Cat. No. 4989
Chemical Name: 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10
Biological ActivityInhibitor of active Ras proteins. Displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also facilitates Ras degradation. Shown to induce autophagy in several human cancer cell lines.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Faigenbaum et al (2013) Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib. Oncotarget 4 316. PMID: 23530112.
Schmukler et al (2013) Ras inhibition enhances autophagy, which partially protects cells from death. Oncotarget 4 142. PMID: 23370967.
Haklai et al (1998) Dislodgement and accelerated degradation of Ras. Biochemistry 37 1306. PMID: 9477957.
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Citations are publications that use Tocris products. Selected citations for Salirasib include:
Lee et al (2015) A systems-biological study on the identification of safe and effective molecular targets for the reduction of ultraviolet B-induced skin pigmentation. J Virol 5 10305. PMID: 25980672.
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Keywords: Salirasib, supplier, Ras, inhibitors, inhibits, induces, autophagy, Tocris Bioscience, GTPase Inhibitor products