TCS ERK 11e

Cat. No. 4465

TCS ERK 11e C24H20Cl2FN5O2 [896720-20-0]

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Alternative Name: VX 11e

Chemical Name: 4-[2-[(2-Chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide

Biological Activity

Potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Orally bioavailable.

Technical Data

M.Wt:
500.35
Formula:
C24H20Cl2FN5O2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
896720-20-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Aronov et al (2009) Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-related kinase (ERK) using conformational control. J.Med.Chem. 52 6362. PMID: 19827834.

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Keywords: TCS ERK 11e, supplier, TCSERK11e, extracellular, signal, related, kinase, 2, ERK2, inhibitors, inhibits, potent, selective, cell, permeable, orally, bioavailable, VTX11e, VX11e, Tocris Bioscience, ERK Inhibitor products

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