ML 141

Cat. No. 4266

ML 141 C22H21N3O3S [71203-35-5]

Price and Availability

For ML 141 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: CID 2950007

Chemical Name: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide

Biological Activity

Allosteric inhibitor of Cdc42 GTPase (EC50 = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Hong et al (2013) Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe. J.Biol.Chem. Epub. PMID: 23382385.

Surviladze et al (2010) A potent and selective inhibitor of Cdc42 GTPase. Probe Reports from the Molecular Libraries Program NBK5196. PMID: 21433396.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ML 141 include:

Mues et al (2015) Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol 89 6673. PMID: 25878109.

Sumida and Yamada (2015) Rho GTPases and the downstream effectors actin-related protein 2/3 (Arp2/3) complex and myosin II induce membrane fusion at self-contacts. J Biol Chem 290 3238. PMID: 25527498.

El-Sayed et al (2014) P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells. Nat Commun 307 C83. PMID: 24760984.

McNary et al (2014) Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton. Tissue Eng Part A 20 921. PMID: 24116978.

Wan et al (2013) Rac1 and Cdc42 GTPases regulate shear stress-driven β-catenin signaling in osteoblasts. Biochem Biophys Res Commun 433 502. PMID: 23524265.

Tseng et al (2012) Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior. Am J Physiol Cell Physiol 9 1113. PMID: 23064517.

Do you know of a great paper that uses ML 141 from Tocris? If so please let us all ▼show less ▲

View Related Products by Target

View Related Products by Product Action

Keywords: ML 141, supplier, ML141, CID2950007, inhibits, cdc42, Rho, GTPase, inhibitor, inhibitors, Tocris Bioscience, GTPase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Spring/Summer 2016)

Our New Product guide highlights over 110 new products added in the first half of 2016. View PDF today.

divider line

Bio-Techne Events

IVBM 2016

IVBM 2016

October 30 - November 3, 2016

Boston, MA, USA

Booth: 2