Cat. No. 4266
Alternative Name: CID 2950007
Chemical Name: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-
Biological ActivityAllosteric inhibitor of Cdc42 GTPase (EC50 = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hong et al (2013) Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe. J.Biol.Chem. Epub. PMID: 23382385.
Surviladze et al (2010) A potent and selective inhibitor of Cdc42 GTPase. Probe Reports from the Molecular Libraries Program NBK5196. PMID: 21433396.
If you know of a relevant reference for ML 141 please let us know.
Citations are publications that use Tocris products. Selected citations for ML 141 include:
Mues et al (2015) Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol 89 6673. PMID: 25878109.
Sumida and Yamada (2015) Rho GTPases and the downstream effectors actin-related protein 2/3 (Arp2/3) complex and myosin II induce membrane fusion at self-contacts. J Biol Chem 290 3238. PMID: 25527498.
El-Sayed et al (2014) P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells. Nat Commun 307 C83. PMID: 24760984.
McNary et al (2014) Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton. Tissue Eng Part A 20 921. PMID: 24116978.
Wan et al (2013) Rac1 and Cdc42 GTPases regulate shear stress-driven β-catenin signaling in osteoblasts. Biochem Biophys Res Commun 433 502. PMID: 23524265.
Tseng et al (2012) Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior. Am J Physiol Cell Physiol 9 1113. PMID: 23064517.
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Keywords: ML 141, supplier, ML141, CID2950007, inhibits, cdc42, Rho, GTPase, inhibitor, inhibitors, Tocris Bioscience, GTPase Inhibitor products