MBT Domains

Malignant Brain Tumor (MBT) domains are a family of methylated lysine-recognizing transcriptional repressors. They possess a methyl-lysine (Kme) binding pocket along with other Kme reader proteins, but MBT domains selectively recognize mono- and dimethylated lysines.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
4666 UNC 1215
Potent inhibitor of L3MBTL3 Kme reader domain; cell permeable
4516 UNC 926 hydrochloride
L3MBTL1 domain inhibitor

Malignant Brain Tumor (MBT) domains are a family of methylated lysine-recognizing transcriptional repressors. They possess a methyl-lysine (Kme) binding pocket along with other Kme reader proteins, but MBT domains selectively recognize mono- and dimethylated residues over unmethylated and trimethylated lysines.

MBT domains are part of the 'Royal family' of Kme readers, which also includes chromo, Tudor and PWWP domains. Their function has been associated with gene repression, whilst MBTD1, L3MBTL1 and L3MBTL3 are also linked to hematopoiesis. It has also been reported that some MBT domains act as tumor suppressors through an as yet uncharacterized mechanism, and dysregulated MBT domain activity is associated with various diseases such as breast cancer and neurological tumors.

MBT domains can also exist alongside other domains in large chromatin-remodeling complexes, such as polycomb repressor complexes, which regulate gene expression. These multisubunit complexes use the energy from ATP hydrolysis to disrupt the association of histones with DNA, thereby influencing transcription.

Literature for MBT Domains

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases

MBT Domain Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
MBT domain containing 1 Human MBTD1 NM_017643 Q05BQ5
Mouse Mbtd1 NM_134012 Q6P5G3
Rat LOC688133 XM_001081166 XP_001081166
L(3)MBT-like 1 Human L3MBTL1 NM_032107 Q9Y468
Mouse L3mbtl1 NM_001081338 A2A5N8
Rat L3mbtl1 XM_001070026 XP_001070026
L(3)MBT-like 2 Human L3MBTL2 NM_031488 Q969R5
Mouse L3mbtl2 NM_145993 P59178
Rat L3mbtl2 NM_001033695 Q3MIF2
L(3)MBT-like 3 Human L3MBTL3 XM_027074 Q96JM7
Mouse L3mbtl3 NM_172787 Q8BLB7
Rat L3mbtl3 XM_003748666 XP_003748714
L(3)MBT-like 4 Human L3MBTL4 NM_173464 Q8NA19
Mouse L3mbtl4 NM_177278 B1B1A0
Rat - - -