ZM 39923 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 1367 - ZM 39923 hydrochloride | C23H25NO.HCl | CAS No. 58753-54-1
Description: Potent, selective JAK3 inhibitor
Chemical Name: 3-benzylisopropylamino-1-naphthalen-2-yl-propan-1-one hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature
Pathways

Biological Activity

Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3). pIC50 values are 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25°C) to form ZM 449829 (Cat. No. 1366).

Licensing Information

Sold with the permission of AstraZeneca Ltd.

Compound Libraries

ZM 39923 hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 367.92
Formula C23H25NO.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 58753-54-1
PubChem ID 176406
InChI Key NJTUORMLOPXPBY-UHFFFAOYSA-N
Smiles Cl.CC(C)N(CCC(=O)C1=CC=C2C=CC=CC2=C1)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.79 100

Preparing Stock Solutions

The following data is based on the product molecular weight 367.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.59 mL 27.18 mL
5 mM 0.54 mL 2.72 mL 5.44 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Brown et al (2000) Naphthyl ketones: a new class of janus kinase 3 inhibitors. Bioorg.Med.Chem.Lett. 10 575 PMID: 10741557


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View Related Products by Product Action

View all JAK Kinase Inhibitors

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2 Citations for ZM 39923 hydrochloride

Citations are publications that use Tocris products. Selected citations for ZM 39923 hydrochloride include:

Schaertl et al (2010) A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen 15 478 PMID: 20395409

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. Autophagy 10 e0143319 PMID: 26619345


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Cancer

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
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  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
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Pathways for ZM 39923 hydrochloride

JAK-STAT

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.