ZM 449829

Pricing Availability Delivery Time Qty
Cat.No. 1366 - ZM 449829 | C13H10O | CAS No. 4452-06-6
Description: Potent, selective JAK3 inhibitor
Chemical Name: 1-(2-Naphthalenyl)-2-propen-1-one
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature
Pathways

Biological Activity

Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site. pIC50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Inhibits STAT-5 phosphorylation and T cell proliferation.

Licensing Information

Sold with the permission of AstraZeneca Ltd.

Technical Data

M. Wt 182.22
Formula C13H10O
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 4452-06-6
PubChem ID 3799
InChI Key FOTCGZPFSUWZBN-UHFFFAOYSA-N
Smiles C=CC(C2=CC1=CC=CC=C1C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 182.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.49 mL 27.44 mL 54.88 mL
5 mM 1.1 mL 5.49 mL 10.98 mL
10 mM 0.55 mL 2.74 mL 5.49 mL
50 mM 0.11 mL 0.55 mL 1.1 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Brown et al (2000) Naphthyl ketones: a new class of janus kinase 3 inhibitors Bioorg.Med.Chem.Lett. 10 575 PMID: 10741557

Orange et al (2011) IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J.Clin.Invest. 121 1535 PMID: 21383498


If you know of a relevant reference for ZM 449829, please let us know.

View Related Products by Product Action

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Keywords: Potent selective JAK3 inhibitors inhibits JAK Kinase Janus Activated Kinases ZM449829 AstraZeneca JAK Kinase

2 Citations for ZM 449829

Citations are publications that use Tocris products. Selected citations for ZM 449829 include:

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. PLoS One 10 e0143319 PMID: 26619345

Schaertl et al (2010) A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen 15 478 PMID: 20395409


Do you know of a great paper that uses ZM 449829 from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for ZM 449829

JAK-STAT

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.

Protocols

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