ZCL 278

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Cat.No. 4794 - ZCL 278 | C21H19BrClN5O4S2 | CAS No. 587841-73-4
Description: Cdc42 inhibitor
Chemical Name: 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide
Purity: ≥95% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.

Compound Libraries

ZCL 278 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 584.89
Formula C21H19BrClN5O4S2
Storage Store at +4°C
Purity ≥95% (HPLC)
CAS Number 587841-73-4
PubChem ID 1791111
InChI Key XKZDWYDHEBCGCG-UHFFFAOYSA-N
Smiles ClC1=C(OCC(NC(NC2=CC=C(S(NC3=NC(C)=CC(C)=N3)(=O)=O)C=C2)=S)=O)C=CC(Br)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58.49 100

Preparing Stock Solutions

The following data is based on the product molecular weight 584.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.71 mL 8.55 mL 17.1 mL
5 mM 0.34 mL 1.71 mL 3.42 mL
10 mM 0.17 mL 0.85 mL 1.71 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Friesland et al (2013) Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc.Natl.Acad.Sci.USA 110 1261 PMID: 23284167


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Keywords: ZCL 278, supplier, ZCL278, Cdc42, Rho, small, GTPases, inhibitors, inhibits, G, Proteins, (Small), GTPase, GTPase, Tocris Bioscience

2 Citations for ZCL 278

Citations are publications that use Tocris products. Selected citations for ZCL 278 include:

Speranza et al (2015) Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. Nat Biotechnol 9 62 PMID: 25814944

Bijata et al (2015) Dystroglycan controls dendritic morphogenesis of hippocampal neurons in vitro. Front Cell Neurosci 9 199 PMID: 26074769


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