ZCL 278

Pricing Availability Delivery Time Qty
Cat.No. 4794 - ZCL 278 | C21H19BrClN5O4S2 | CAS No. 587841-73-4
Description: Cdc42 inhibitor
Chemical Name: 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide
Purity: ≥95% (HPLC)
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

Selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.

Compound Libraries

ZCL 278 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 584.89
Formula C21H19BrClN5O4S2
Storage Store at +4°C
Purity ≥95% (HPLC)
CAS Number 587841-73-4
PubChem ID 1791111
InChI Key XKZDWYDHEBCGCG-UHFFFAOYSA-N
Smiles ClC1=C(OCC(NC(NC2=CC=C(S(NC3=NC(C)=CC(C)=N3)(=O)=O)C=C2)=S)=O)C=CC(Br)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58.49 100

Preparing Stock Solutions

The following data is based on the product molecular weight 584.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.71 mL 8.55 mL 17.1 mL
5 mM 0.34 mL 1.71 mL 3.42 mL
10 mM 0.17 mL 0.85 mL 1.71 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Friesland et al (2013) Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc.Natl.Acad.Sci.USA 110 1261 PMID: 23284167


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View all GTPase Inhibitors

Keywords: ZCL 278, ZCL 278 supplier, ZCL278, Cdc42, Rho, small, GTPases, inhibitors, inhibits, G, Proteins, (Small), GTPase, 4794, Tocris Bioscience

4 Citations for ZCL 278

Citations are publications that use Tocris products. Selected citations for ZCL 278 include:

Bijata et al (2017) Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix Cell Rep 19 1767 PMID: 28564597

Speranza et al (2017) Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons J Neurochem 141 647 PMID: 28122114

Bijata et al (2015) Dystroglycan controls dendritic morphogenesis of hippocampal neurons in vitro. Front Cell Neurosci 9 199 PMID: 26074769

Speranza et al (2015) Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. Nat Biotechnol 9 62 PMID: 25814944


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Literature in this Area

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