ZCL 278

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Cat.No. 4794 - ZCL 278 | C21H19BrClN5O4S2 | CAS No. 587841-73-4
Description: Cdc42 inhibitor
Chemical Name: 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide
Purity: ≥95% (HPLC)
Citations (4)
Literature (1)

Biological Activity

Selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.

Technical Data

M. Wt 584.89
Formula C21H19BrClN5O4S2
Storage Store at +4°C
Purity ≥95% (HPLC)
CAS Number 587841-73-4
PubChem ID 1791111
Smiles ClC1=C(OCC(NC(NC2=CC=C(S(NC3=NC(C)=CC(C)=N3)(=O)=O)C=C2)=S)=O)C=CC(Br)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 58.49 100

Preparing Stock Solutions

The following data is based on the product molecular weight 584.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.71 mL 8.55 mL 17.1 mL
5 mM 0.34 mL 1.71 mL 3.42 mL
10 mM 0.17 mL 0.85 mL 1.71 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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References are publications that support the biological activity of the product.

Friesland et al (2013) Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc.Natl.Acad.Sci.USA 110 1261 PMID: 23284167

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Keywords: ZCL 278, ZCL 278 supplier, ZCL278, Cdc42, Rho, small, GTPases, inhibitors, inhibits, 4794, Tocris Bioscience

4 Citations for ZCL 278

Citations are publications that use Tocris products. Selected citations for ZCL 278 include:

Bijata et al (2017) Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix Cell Rep 19 1767 PMID: 28564597

Speranza et al (2017) Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons J Neurochem 141 647 PMID: 28122114

Bijata et al (2015) Dystroglycan controls dendritic morphogenesis of hippocampal neurons in vitro. Front Cell Neurosci 9 199 PMID: 26074769

Speranza et al (2015) Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. Nat Biotechnol 9 62 PMID: 25814944

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Literature in this Area

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