YH 239-EE

Discontinued Product

YH 239-EE (Cat. No. 6719) has been withdrawn from sale for commercial reasons.
Description: Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity
Chemical Name: Ethyl 3-[2-(tert-butylamino)-1-[N-(4-chlorobenzyl)formamido]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for YH 239-EE

YH 239-EE is a MDM2 inhibitor. Disrupts MDM2-p53 and activates p53 activity in vitro. Prevents mitotic catastrophe and promotes survival of aged muscle stem cells (muSCs). Also inhibits proliferation of AML cells in vitro.

Technical Data for YH 239-EE

M. Wt 504.41
Formula C25H27Cl2N3O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1364488-67-4
PubChem ID 56943013
Smiles CCOC(C1=C(C2=CC=C(C=C2N1)Cl)C(C(NC(C)(C)C)=O)N(C=O)CC3=CC=C(C=C3)Cl)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for YH 239-EE

References are publications that support the biological activity of the product.

Huang et al (2014) Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. ACS Chem.Biol. 9 802 PMID: 24405416

Liu et al (2018) Impaired notch signaling leads to a decrease in p53 activity and mitotic catastrophe in aged muscle stem cells. Cell Stem Cell. 23 544 PMID: 30244867

Keywords: YH 239-EE, YH 239-EE supplier, YH239-EE, muscle, stem, cells, MuSC, survival, proliferation, mdm2, inhibitors, inhibits, Stem, Cell, Proliferation, Ubiquitin, E3, Ligases, 6719, Tocris Bioscience

Citations for YH 239-EE

Citations are publications that use Tocris products.

Currently there are no citations for YH 239-EE.

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