YH 239-EE

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Cat.No. 6719 - YH 239-EE | C25H27Cl2N3O4 | CAS No. 1364488-67-4
Description: Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity
Chemical Name: Ethyl 3-[2-(tert-butylamino)-1-[N-(4-chlorobenzyl)formamido]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

MDM2 inhibitor. Disrupts MDM2-p53 and activates p53 activity in vitro. Prevents mitotic catastrophe and promotes survival of aged muscle stem cells (muSCs). Also inhibits proliferation of AML cells in vitro.

Technical Data

M. Wt 504.41
Formula C25H27Cl2N3O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1364488-67-4
PubChem ID 56943013
InChI Key OTUBDDRFPQLPKD-UHFFFAOYSA-N
Smiles CCOC(C1=C(C2=CC=C(C=C2N1)Cl)C(C(NC(C)(C)C)=O)N(C=O)CC3=CC=C(C=C3)Cl)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.44 100
ethanol 10.09 20

Preparing Stock Solutions

The following data is based on the product molecular weight 504.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.91 mL 19.83 mL
5 mM 0.4 mL 1.98 mL 3.97 mL
10 mM 0.2 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References

References are publications that support the biological activity of the product.

Huang et al (2014) Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. ACS Chem.Biol. 9 802 PMID: 24405416

Liu et al (2018) Impaired notch signaling leads to a decrease in p53 activity and mitotic catastrophe in aged muscle stem cells. Cell Stem Cell. 23 544 PMID: 30244867


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Keywords: YH 239-EE, YH 239-EE supplier, YH239-EE, muscle, stem, cells, MuSC, survival, proliferation, mdm2, inhibitors, inhibits, Stem, Cell, Proliferation, Ubiquitin, E3, Ligases, 6719, Tocris Bioscience

Citations for YH 239-EE

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Literature in this Area

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