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Submit ReviewYH 239-EE
Description: Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity
Chemical Name: Ethyl 3-[2-(tert-butylamino)-1-[N-(4-chlorobenzyl)formamido]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate
Purity: ≥98% (HPLC)
Biological Activity for YH 239-EE
YH 239-EE is a MDM2 inhibitor. Disrupts MDM2-p53 and activates p53 activity in vitro. Prevents mitotic catastrophe and promotes survival of aged muscle stem cells (muSCs). Also inhibits proliferation of AML cells in vitro.
Technical Data for YH 239-EE
| M. Wt | 504.41 |
| Formula | C25H27Cl2N3O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1364488-67-4 |
| PubChem ID | 56943013 |
| InChI Key | OTUBDDRFPQLPKD-UHFFFAOYSA-N |
| Smiles | CCOC(C1=C(C2=CC=C(C=C2N1)Cl)C(C(NC(C)(C)C)=O)N(C=O)CC3=CC=C(C=C3)Cl)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for YH 239-EE
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.44 | 100 | |
| ethanol | 10.09 | 20 |
Preparing Stock Solutions for YH 239-EE
The following data is based on the product molecular weight 504.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.98 mL | 9.91 mL | 19.83 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.97 mL |
| 10 mM | 0.2 mL | 0.99 mL | 1.98 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets for YH 239-EE
References for YH 239-EE
References are publications that support the biological activity of the product.
Huang et al (2014) Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. ACS Chem.Biol. 9 802 PMID: 24405416
Liu et al (2018) Impaired notch signaling leads to a decrease in p53 activity and mitotic catastrophe in aged muscle stem cells. Cell Stem Cell. 23 544 PMID: 30244867
If you know of a relevant reference for YH 239-EE, please let us know.
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Citations for YH 239-EE
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