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Potent and selective mTOR inhibitor (IC50 = 9.9 nM). Inhibits mTOR activity in an ATP-competitive manner. Exhibits >300-fold selectivity for mTOR over PI 3-K and a range of other kinases. Displays antitumor activity in athymic nude mice implanted with tumor xenografts.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 455.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.39 mL||21.95 mL||43.91 mL|
|2.5 mM||0.88 mL||4.39 mL||8.78 mL|
|5 mM||0.44 mL||2.2 mL||4.39 mL|
|25 mM||0.09 mL||0.44 mL||0.88 mL|
References are publications that support the biological activity of the product.
Takeuchi et al (2013) Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR). J.Med.Chem. 56 2218 PMID: 23394126
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Keywords: XL 388, XL 388 supplier, XL388, potent, selective, mtor, inhibitors, inhibits, kinases, antitumor, ATP-competetive, mTOR, 4893, Tocris Bioscience
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