XL 388

Discontinued Product

XL 388 (Cat. No. 4893) has been withdrawn from sale for commercial reasons.
Description: Potent and selective mTOR inhibitor; antitumor
Chemical Name: [7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone
Purity: ≥98% (HPLC)
Literature (2)
Pathways (1)

Biological Activity for XL 388

XL 388 is a potent and selective mTOR inhibitor (IC50 = 9.9 nM). Inhibits mTOR activity in an ATP-competitive manner. Exhibits >300-fold selectivity for mTOR over PI 3-K and a range of other kinases. Displays antitumor activity in athymic nude mice implanted with tumor xenografts.

Technical Data for XL 388

M. Wt 455.5
Formula C23H22FN3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1251156-08-7
PubChem ID 59604787
Smiles NC1=NC=C(C2=CC=C(OCCN(C(C4=CC=C(S(C)(=O)=O)C(F)=C4C)=O)C3)C3=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for XL 388

References are publications that support the biological activity of the product.

Takeuchi et al (2013) Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR). J.Med.Chem. 56 2218 PMID: 23394126

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Keywords: XL 388, XL 388 supplier, XL388, potent, selective, mtor, inhibitors, inhibits, kinases, antitumor, ATP-competetive, mTOR, 4893, Tocris Bioscience

Citations for XL 388

Citations are publications that use Tocris products.

Currently there are no citations for XL 388.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Pathways for XL 388

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.