VU 0155041

Pricing Availability Delivery Time Qty
Cat.No. 3248 - VU 0155041 | C14H15Cl2NO3 | CAS No. 1093757-42-6
Description: Potent, positive allosteric mGlu4 agonist
Chemical Name: cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Active in in vivo models of Parkinson's disease following i.c.v. administration. Also available as sodium salt (Cat. No. 3311).

Technical Data

M. Wt 316.18
Formula C14H15Cl2NO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1093757-42-6
PubChem ID 90488819
InChI Key QYHQKAPECWRTME-FBVLPHPLSA-N
Smiles O=[C@](NC2=CC(Cl)=CC(Cl)=C2)[C@H]1CCCC[C@H]1[C@@](O)=O.O=[C@](NC4=CC(Cl)=CC(Cl)=C4)[C@@H]3CCCC[C@@H]3C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 31.62 100
DMSO 31.62 100
ethanol 31.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 316.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.81 mL 31.63 mL
5 mM 0.63 mL 3.16 mL 6.33 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Niswender et al (2008) Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol.Pharmacol. 74 1345 PMID: 18664603


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