VU 0155041

Discontinued Product

VU 0155041 (Cat. No. 3248) has been withdrawn from sale for commercial reasons.
Description: Potent positive allosteric modulator of mGlu4 receptors
Chemical Name: cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (3)

Biological Activity for VU 0155041

VU 0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Active in in vivo models of Parkinson's disease following i.c.v. administration. Also available as sodium salt (Cat. No. 3311).

Technical Data for VU 0155041

M. Wt 316.18
Formula C14H15Cl2NO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1093757-42-6
PubChem ID 90488819
InChI Key QYHQKAPECWRTME-FBVLPHPLSA-N
Smiles O=[C@](NC2=CC(Cl)=CC(Cl)=C2)[C@H]1CCCC[C@H]1[C@@](O)=O.O=[C@](NC4=CC(Cl)=CC(Cl)=C4)[C@@H]3CCCC[C@@H]3C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for VU 0155041

References are publications that support the biological activity of the product.

Niswender et al (2008) Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol.Pharmacol. 74 1345 PMID: 18664603

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.