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VU 0155041 sodium salt
Biological Activity for VU 0155041 sodium salt
VU 0155041 sodium salt is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Active in in vivo models of Parkinson's disease following i.c.v. administration. Sodium salt of VU 0155041 (Cat. No. 3248).
Technical Data for VU 0155041 sodium salt
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for VU 0155041 sodium salt
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for VU 0155041 sodium salt
The following data is based on the product molecular weight 338.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||11.83 mL||59.14 mL||118.29 mL|
|1.25 mM||2.37 mL||11.83 mL||23.66 mL|
|2.5 mM||1.18 mL||5.91 mL||11.83 mL|
|12.5 mM||0.24 mL||1.18 mL||2.37 mL|
Product Datasheets for VU 0155041 sodium salt
References for VU 0155041 sodium salt
References are publications that support the biological activity of the product.
Niswender et al (2008) Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol.Pharmacol. 74 1345 PMID: 18664603
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Citations for VU 0155041 sodium salt
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Literature in this Area
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Learning & Memory Poster
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.