TP 003

Pricing Availability Delivery Time Qty
Cat.No. 4414 - TP 003 | C23H16F3N3O | CAS No. 628690-75-5
Description: Functionally selective GABAA receptor (α3 subtype) partial agonist
Chemical Name: 2',4-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]-pyridin-3-yl]-[1,1'-biphenyl]-2-carbonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Functionally selective GABAA receptor (α3 subtype) partial agonist. Exhibits affinity for the benzodiazepine binding site on human GABAA receptors. Potentiates the GABA (α3 subtype) response selectively with high efficacy. Produces anxiolytic-like effects in rodent behavioral models of anxiety.

Compound Libraries

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Technical Data

M. Wt 407.39
Formula C23H16F3N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 628690-75-5
PubChem ID 10001434
InChI Key SJMMDWXJSSJHOQ-UHFFFAOYSA-N
Smiles FC1=C(C(C)(O)C)C=CN2C1=NC=C2C3=CC=C(F)C(C4=CC=C(F)C=C4C#N)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.74 100
ethanol 20.37 50

Preparing Stock Solutions

The following data is based on the product molecular weight 407.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.27 mL 24.55 mL
5 mM 0.49 mL 2.45 mL 4.91 mL
10 mM 0.25 mL 1.23 mL 2.45 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Dias et al (2005) Evidence for a significant role of α3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. J.Neurosci. 25 10682 PMID: 16291941

Fischer et al (2011) Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys. Psychopharmacology (Berl.) 215 311 PMID: 21190016


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Keywords: TP003 GABAA GABA receptors a3 alpha3 α3 agonists anxiolytic GABAA Receptors

1 Citation for TP 003

Citations are publications that use Tocris products. Selected citations for TP 003 include:

Seifi et al (2014) Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. Gastroenterology 34 10361 PMID: 25080596


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Reviews

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Pathways for TP 003

Protocols

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