TMCB

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Cat.No. 3675 - TMCB | C11H9Br4N3O2 | CAS No. 905105-89-7
Description: Dual-kinase inhibitor; inhibits CK2 and ERK8
Chemical Name: 2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Dual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki values are 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2 respectively).

Technical Data

M. Wt 534.82
Formula C11H9Br4N3O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 905105-89-7
PubChem ID 46943415
InChI Key PHAOTASRLQMKBE-UHFFFAOYSA-N
Smiles BrC1=C2C(N(CC(O)=O)C(N(C)C)=N2)=C(Br)C(Br)=C1Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.37 25

Preparing Stock Solutions

The following data is based on the product molecular weight 534.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.35 mL 18.7 mL
5 mM 0.37 mL 1.87 mL 3.74 mL
10 mM 0.19 mL 0.93 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Pagano et al (2008) The selectivity of inhibitors of protein kinase CK2: an update. Biochem.J. 415 353 PMID: 18588507


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Keywords: TMCB, supplier, casein, kinase, 2, ck2, extracellular-signal-regulated, kinase, 8, ERK8, dual, kinase, inhibitors, inhibits, Casein, Kinase, 2, Tocris Bioscience

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Pathways for TMCB

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