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Biological Activity for TMCB
TMCB is a dual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki values are 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2 respectively).
Compound Libraries for TMCB
Technical Data for TMCB
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for TMCB
References are publications that support the biological activity of the product.
Pagano et al (2008) The selectivity of inhibitors of protein kinase CK2: an update. Biochem.J. 415 353 PMID: 18588507
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Keywords: TMCB, TMCB supplier, casein, kinase, 2, ck2, extracellular-signal-regulated, 8, ERK8, dual, inhibitors, inhibits, Casein, Kinase, ERK, 3675, Tocris Bioscience
1 Citation for TMCB
Citations are publications that use Tocris products. Selected citations for TMCB include:
Schevzov et al (2015) Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments. Mol Biol Cell 26 2475 PMID: 25971798
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Literature in this Area
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Cell Cycle and DNA Damage Research Product Guide
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