TMCB

Discontinued Product

TMCB (Cat. No. 3675) has been withdrawn from sale for commercial reasons.
Cat.No. 3675 - TMCB | C11H9Br4N3O2 | CAS No. 905105-89-7
Description: Dual-kinase inhibitor; inhibits CK2 and ERK8
Chemical Name: 2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity for TMCB

TMCB is a dual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki values are 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2 respectively).

Compound Libraries for TMCB

TMCB is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TMCB

M. Wt 534.82
Formula C11H9Br4N3O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 905105-89-7
PubChem ID 46943415
InChI Key PHAOTASRLQMKBE-UHFFFAOYSA-N
Smiles BrC1=C2C(N(CC(O)=O)C(N(C)C)=N2)=C(Br)C(Br)=C1Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for TMCB

References are publications that support the biological activity of the product.

Pagano et al (2008) The selectivity of inhibitors of protein kinase CK2: an update. Biochem.J. 415 353 PMID: 18588507

View Related Products by Target

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View all Casein Kinase 2 Inhibitors

Keywords: TMCB, TMCB supplier, casein, kinase, 2, ck2, extracellular-signal-regulated, 8, ERK8, dual, inhibitors, inhibits, Casein, Kinase, ERK, 3675, Tocris Bioscience

1 Citation for TMCB

Citations are publications that use Tocris products. Selected citations for TMCB include:

Schevzov et al (2015) Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments. Mol Biol Cell 26 2475 PMID: 25971798


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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