Dual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki values are 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2 respectively).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 534.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.87 mL||9.35 mL||18.7 mL|
|5 mM||0.37 mL||1.87 mL||3.74 mL|
|10 mM||0.19 mL||0.93 mL||1.87 mL|
|50 mM||0.04 mL||0.19 mL||0.37 mL|
References are publications that support the biological activity of the product.
Pagano et al (2008) The selectivity of inhibitors of protein kinase CK2: an update. Biochem.J. 415 353 PMID: 18588507
If you know of a relevant reference for TMCB, please let us know.
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Keywords: TMCB, TMCB supplier, casein, kinase, 2, ck2, extracellular-signal-regulated, 8, ERK8, dual, inhibitors, inhibits, Casein, Kinase, ERK, 3675, Tocris Bioscience
1 Citation for TMCB
Citations are publications that use Tocris products. Selected citations for TMCB include:
Schevzov et al (2015) Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments. Mol Biol Cell 26 2475 PMID: 25971798
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Literature in this Area
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