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Submit ReviewThreo-methylphenidate hydrochloride
Description: Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant
Alternative Names: Ritalin
Chemical Name: Threo-methyl α-Phenyl-2-piperidineacetate hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Threo-methylphenidate hydrochloride
Threo-methylphenidate hydrochloride is a psychomotor stimulant. Inhibitor of dopamine and noradrenalin transporters that increases the extracellular concentration of dopamine and noradrenalin. Increases locomotor activity in vivo.
Technical Data for Threo-methylphenidate hydrochloride
| M. Wt | 269.77 |
| Formula | C14H19NO2.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 298-59-9 |
| PubChem ID | 45259401 |
| InChI Key | JUMYIBMBTDDLNG-QNTKWALQSA-N |
| Smiles | [H][C@]1([C@H]([C@]2=CC=CC=C2)C(OC)=O)NCCCC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Threo-methylphenidate hydrochloride
References for Threo-methylphenidate hydrochloride
References are publications that support the biological activity of the product.
Askenasy et al (2007) Methylphenidate (Ritalin): behavioral studies in the rat. Int.J.Neurosci. 117 757 PMID: 17454243
Leonard et al (2004) Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects. Human Psychopharm. 19 151
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Keywords: Threo-methylphenidate hydrochloride, Threo-methylphenidate hydrochloride supplier, inhibitors, inhibits, dopamine, DAT, noradrenalin, noradrenaline, NET, adrenalin, transporters, Psychomotor, stimulants, neurotransmitter, Ritalin, Dopamine, Transporters, Adrenergic, 1812, Tocris Bioscience
3 Citations for Threo-methylphenidate hydrochloride
Citations are publications that use Tocris products. Selected citations for Threo-methylphenidate hydrochloride include:
Beerepoot et al (2016) Pharmacological Chaperones of the DA Transporter Rescue DA Transporter Deficiency Syndrome Mutations in Heterologous Cells. J Biol Chem 291 22053 PMID: 27555326
Poulin et al (2014) Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics. Mol Pharmacol 86 378 PMID: 25028482
Parker et al (2014) Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish. PLoS One 231 2671 PMID: 24481568
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.