Threo-methylphenidate hydrochloride

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Cat.No. 1812 - Threo-methylphenidate hydrochloride | C14H19NO2.HCl | CAS No. 298-59-9
Description: Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant
Alternative Names: Ritalin
Chemical Name: Threo-methyl α-Phenyl-2-piperidineacetate hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Psychomotor stimulant. Inhibitor of dopamine and noradrenalin transporters that increases the extracellular concentration of dopamine and noradrenalin. Increases locomotor activity in vivo.

Technical Data

M. Wt 269.77
Formula C14H19NO2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 298-59-9
PubChem ID 45259401
InChI Key JUMYIBMBTDDLNG-QNTKWALQSA-N
Smiles [H][C@]1([C@H]([C@]2=CC=CC=C2)C(OC)=O)NCCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 13.49 50
ethanol 26.98 100

Preparing Stock Solutions

The following data is based on the product molecular weight 269.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.53 mL 37.07 mL
5 mM 0.74 mL 3.71 mL 7.41 mL
10 mM 0.37 mL 1.85 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Askenasy et al (2007) Methylphenidate (Ritalin): behavioral studies in the rat. Int.J.Neurosci. 117 757 PMID: 17454243

Leonard et al (2004) Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects. Human Psychopharm. 19 151


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Keywords: Threo-methylphenidate hydrochloride, Threo-methylphenidate hydrochloride supplier, inhibitors, inhibits, dopamine, DAT, noradrenalin, noradrenaline, NET, adrenalin, transporters, Psychomotor, stimulants, neurotransmitter, Ritalin, Dopamine, Transporters, Adrenergic, 1812, Tocris Bioscience

3 Citations for Threo-methylphenidate hydrochloride

Citations are publications that use Tocris products. Selected citations for Threo-methylphenidate hydrochloride include:

Poulin et al (2014) Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics. Mol Pharmacol 86 378 PMID: 25028482

Beerepoot et al (2016) Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells. J Biol Chem 291 22053 PMID: 27555326

Parker et al (2014) Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish. PLoS One 231 2671 PMID: 24481568


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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