Threo-methylphenidate hydrochloride

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Cat.No. 1812 - Threo-methylphenidate hydrochloride | C14H19NO2.HCl | CAS No. 298-59-9
Description: Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant
Alternative Names: Ritalin
Chemical Name: Threo-methyl α-Phenyl-2-piperidineacetate hydrochloride
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity

Psychomotor stimulant. Inhibitor of dopamine and noradrenalin transporters that increases the extracellular concentration of dopamine and noradrenalin. Increases locomotor activity in vivo.

Technical Data

M. Wt 269.77
Formula C14H19NO2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 298-59-9
PubChem ID 45259401
Smiles [H][C@]1([C@H]([C@]2=CC=CC=C2)C(OC)=O)NCCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 26.98 100
water 13.49 50

Preparing Stock Solutions

The following data is based on the product molecular weight 269.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.53 mL 37.07 mL
5 mM 0.74 mL 3.71 mL 7.41 mL
10 mM 0.37 mL 1.85 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Askenasy et al (2007) Methylphenidate (Ritalin): behavioral studies in the rat. Int.J.Neurosci. 117 757 PMID: 17454243

Leonard et al (2004) Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects. Human Psychopharm. 19 151 PMID:

If you know of a relevant reference for Threo-methylphenidate hydrochloride, please let us know.

View Related Products by Product Action

View all Dopamine Transporter Inhibitors

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2 Citations for Threo-methylphenidate hydrochloride

Citations are publications that use Tocris products. Selected citations for Threo-methylphenidate hydrochloride include:

Poulin et al (2014) Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics. Mol Pharmacol 86 378 PMID: 25028482

Parker et al (2014) Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish. PLoS One 231 2671 PMID: 24481568

Do you know of a great paper that uses Threo-methylphenidate hydrochloride from Tocris? If so please let us know.

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