TCS 2210

Pricing Availability Delivery Time Qty
Cat.No. 3877 - TCS 2210 | C18H17N3O3 | CAS No. 1201916-31-5
Description: Inducer of neuronal differentiation in MSCs
Chemical Name: 1,2-Dihydro-N-hydroxy-2-oxo-3-(3-phenylpropyl)-6-quinoxalinecarboxamide
Datasheet
Citations (1)
Literature

Biological Activity

Inducer of neuronal differentiation in mesenchymal stem cells (MSCs) with specific phenotype change. Increases expression of neuronal markers β-III tubulin and NSE without cytotoxicity.

Compound Libraries

TCS 2210 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 323.35
Formula C18H17N3O3
Storage Store at +4°C
CAS Number 1201916-31-5
PubChem ID 44607172
InChI Key ZOFZKGFBKISZRI-UHFFFAOYSA-N
Smiles O=C(NO)C3=CC1=C(C=C3)NC(C(CCCC2=CC=CC=C2)=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 323.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.09 mL 15.46 mL 30.93 mL
5 mM 0.62 mL 3.09 mL 6.19 mL
10 mM 0.31 mL 1.55 mL 3.09 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kim et al (2009) Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell. J.Med.Chem. 52 7931 PMID: 20014867


If you know of a relevant reference for TCS 2210, please let us know.

Keywords: TCS2210 neuronal inducers differentiation mesenchymal stem cells MSC induces Neural Stem Cells

1 Citation for TCS 2210

Citations are publications that use Tocris products. Selected citations for TCS 2210 include:

Moshfegh et al (2016) A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways. PLoS One 6 25104 PMID: 27157261


Do you know of a great paper that uses TCS 2210 from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

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Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for TCS 2210

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