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TCS 2210 is an inducer of neuronal differentiation in mesenchymal stem cells (MSCs) with specific phenotype change. Increases expression of neuronal markers β-III tubulin and NSE without cytotoxicity.
TCS 2210 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
M. Wt | 323.35 |
Formula | C18H17N3O3 |
Storage | Store at -20°C |
CAS Number | 1201916-31-5 |
PubChem ID | 44607172 |
InChI Key | ZOFZKGFBKISZRI-UHFFFAOYSA-N |
Smiles | O=C(NO)C3=CC1=C(C=C3)NC(C(CCCC2=CC=CC=C2)=N1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 16.17 | 50 |
The following data is based on the product molecular weight 323.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.5 mM | 6.19 mL | 30.93 mL | 61.85 mL |
2.5 mM | 1.24 mL | 6.19 mL | 12.37 mL |
5 mM | 0.62 mL | 3.09 mL | 6.19 mL |
25 mM | 0.12 mL | 0.62 mL | 1.24 mL |
References are publications that support the biological activity of the product.
Kim et al (2009) Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell. J.Med.Chem. 52 7931 PMID: 20014867
If you know of a relevant reference for TCS 2210, please let us know.
Keywords: TCS 2210, TCS 2210 supplier, TCS2210, neuronal, inducers, differentiation, mesenchymal, stem, cells, MSC, induces, Mesenchymal, Stem, Cells, Neural, 3877, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for TCS 2210 include:
Moshfegh et al (2016) A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways. PLoS One 6 25104 PMID: 27157261
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.