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Description: Inducer of neuronal differentiation in MSCs
Chemical Name: 1,2-Dihydro-N-hydroxy-2-oxo-3-(3-phenylpropyl)-6-quinoxalinecarboxamide
Biological Activity for TCS 2210
TCS 2210 is an inducer of neuronal differentiation in mesenchymal stem cells (MSCs) with specific phenotype change. Increases expression of neuronal markers β-III tubulin and NSE without cytotoxicity.
Compound Libraries for TCS 2210
TCS 2210 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for TCS 2210
| M. Wt | 323.35 |
| Formula | C18H17N3O3 |
| Storage | Store at -20°C |
| CAS Number | 1201916-31-5 |
| PubChem ID | 44607172 |
| InChI Key | ZOFZKGFBKISZRI-UHFFFAOYSA-N |
| Smiles | O=C(NO)C3=CC1=C(C=C3)NC(C(CCCC2=CC=CC=C2)=N1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TCS 2210
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.17 | 50 |
Preparing Stock Solutions for TCS 2210
The following data is based on the product molecular weight 323.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.19 mL | 30.93 mL | 61.85 mL |
| 2.5 mM | 1.24 mL | 6.19 mL | 12.37 mL |
| 5 mM | 0.62 mL | 3.09 mL | 6.19 mL |
| 25 mM | 0.12 mL | 0.62 mL | 1.24 mL |
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Product Datasheets for TCS 2210
References for TCS 2210
References are publications that support the biological activity of the product.
Kim et al (2009) Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell. J.Med.Chem. 52 7931 PMID: 20014867
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Keywords: TCS 2210, TCS 2210 supplier, TCS2210, neuronal, inducers, differentiation, mesenchymal, stem, cells, MSC, induces, Mesenchymal, Stem, Cells, Neural, 3877, Tocris Bioscience
1 Citation for TCS 2210
Citations are publications that use Tocris products. Selected citations for TCS 2210 include:
Moshfegh et al (2016) A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways. PLoS One 6 25104 PMID: 27157261
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