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Description: Inducer of neuronal differentiation in MSCs
Chemical Name: 1,2-Dihydro-N-hydroxy-2-oxo-3-(3-phenylpropyl)-6-quinoxalinecarboxamide
Biological Activity
Inducer of neuronal differentiation in mesenchymal stem cells (MSCs) with specific phenotype change. Increases expression of neuronal markers β-III tubulin and NSE without cytotoxicity.
Compound Libraries
TCS 2210 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 323.35 |
| Formula | C18H17N3O3 |
| Storage | Store at -20°C |
| CAS Number | 1201916-31-5 |
| PubChem ID | 44607172 |
| InChI Key | ZOFZKGFBKISZRI-UHFFFAOYSA-N |
| Smiles | O=C(NO)C3=CC1=C(C=C3)NC(C(CCCC2=CC=CC=C2)=N1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.17 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 323.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.19 mL | 30.93 mL | 61.85 mL |
| 2.5 mM | 1.24 mL | 6.19 mL | 12.37 mL |
| 5 mM | 0.62 mL | 3.09 mL | 6.19 mL |
| 25 mM | 0.12 mL | 0.62 mL | 1.24 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Kim et al (2009) Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell. J.Med.Chem. 52 7931 PMID: 20014867
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1 Citation for TCS 2210
Citations are publications that use Tocris products. Selected citations for TCS 2210 include:
Moshfegh et al (2016) A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways. PLoS One 6 25104 PMID: 27157261
Do you know of a great paper that uses TCS 2210 from Tocris? Please let us know.
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