TCS 2002

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Cat.No. 3869 - TCS 2002 | C18H14N2O3S | CAS No. 1005201-24-0
Description: Potent GSK-3β inhibitor
Chemical Name: 2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (8)
Pathways (1)

Biological Activity for TCS 2002

TCS 2002 is a potent inhibitor of GSK-3β (IC50 = 35 nM). Oral adminstration inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain.

Compound Libraries for TCS 2002

TCS 2002 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TCS 2002

M. Wt 338.38
Formula C18H14N2O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1005201-24-0
PubChem ID 24855958
InChI Key RCKYSTKYIVULEK-UHFFFAOYSA-N
Smiles O=S(C)C(C=C3)=CC=C3C2=COC1=CC=C(C4=NN=C(C)O4)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TCS 2002

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.84 100
ethanol 8.46 25

Preparing Stock Solutions for TCS 2002

The following data is based on the product molecular weight 338.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.55 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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References for TCS 2002

References are publications that support the biological activity of the product.

Saitoh et al (2009) 2-{3-[4-(alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β with good brain permeability. J.Med.Chem. 52 6270 PMID: 19775160


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Keywords: TCS 2002, TCS 2002 supplier, TCS2002, glycogen, synthase, kinases, gsk-3, gsk3, gsk-3beta, gsk-3b, gsk-3β, inhibitors, inhibits, Glycogen, Synthase, Kinase, 3, 3869, Tocris Bioscience

1 Citation for TCS 2002

Citations are publications that use Tocris products. Selected citations for TCS 2002 include:

Bellio et al (2017) Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential. Sci Rep 7 9702 PMID: 28851980


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Reviews for TCS 2002

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

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  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
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  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
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Neurodegeneration Product Guide

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Stem Cell

Stem Cell Research Product Guide

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Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Alzheimer's

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

Stem Cells

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for TCS 2002

Wnt

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.