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Description: Potent GSK-3β inhibitor
Chemical Name: 2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole
Purity: ≥99% (HPLC)
Biological Activity for TCS 2002
TCS 2002 is a potent inhibitor of GSK-3β (IC50 = 35 nM). Oral adminstration inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain.
Compound Libraries for TCS 2002
TCS 2002 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for TCS 2002
| M. Wt | 338.38 |
| Formula | C18H14N2O3S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1005201-24-0 |
| PubChem ID | 24855958 |
| InChI Key | RCKYSTKYIVULEK-UHFFFAOYSA-N |
| Smiles | O=S(C)C(C=C3)=CC=C3C2=COC1=CC=C(C4=NN=C(C)O4)C=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TCS 2002
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.84 | 100 | |
| ethanol | 8.46 | 25 |
Preparing Stock Solutions for TCS 2002
The following data is based on the product molecular weight 338.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.78 mL | 29.55 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.91 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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Product Datasheets for TCS 2002
References for TCS 2002
References are publications that support the biological activity of the product.
Saitoh et al (2009) 2-{3-[4-(alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β with good brain permeability. J.Med.Chem. 52 6270 PMID: 19775160
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Keywords: TCS 2002, TCS 2002 supplier, TCS2002, glycogen, synthase, kinases, gsk-3, gsk3, gsk-3beta, gsk-3b, gsk-3β, inhibitors, inhibits, Glycogen, Synthase, Kinase, 3, 3869, Tocris Bioscience
1 Citation for TCS 2002
Citations are publications that use Tocris products. Selected citations for TCS 2002 include:
Bellio et al (2017) Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential. Sci Rep 7 9702 PMID: 28851980
Do you know of a great paper that uses TCS 2002 from Tocris? Please let us know.
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Pathways for TCS 2002
