TCS 2002

Pricing Availability Delivery Time Qty
Cat.No. 3869 - TCS 2002 | C18H14N2O3S | CAS No. 1005201-24-0
Description: Potent GSK-3β inhibitor
Chemical Name: 2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent inhibitor of GSK-3β (IC50 = 35 nM). Oral adminstration inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain.

Compound Libraries

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Technical Data

M. Wt 338.38
Formula C18H14N2O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1005201-24-0
PubChem ID 24855958
InChI Key RCKYSTKYIVULEK-UHFFFAOYSA-N
Smiles O=S(C)C(C=C3)=CC=C3C2=COC1=CC=C(C4=NN=C(C)O4)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.84 100
ethanol 8.46 25

Preparing Stock Solutions

The following data is based on the product molecular weight 338.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.55 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Saitoh et al (2009) 2-{3-[4-(alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β with good brain permeability. J.Med.Chem. 52 6270 PMID: 19775160


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Citations for TCS 2002

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