TCS 2002

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Cat.No. 3869 - TCS 2002 | C18H14N2O3S | CAS No. 1005201-24-0
Description: Potent GSK-3β inhibitor
Chemical Name: 2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity

Potent inhibitor of GSK-3β (IC50 = 35 nM). Oral adminstration inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain.

Compound Libraries

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Technical Data

M. Wt 338.38
Formula C18H14N2O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1005201-24-0
PubChem ID 24855958
InChI Key RCKYSTKYIVULEK-UHFFFAOYSA-N
Smiles O=S(C)C(C=C3)=CC=C3C2=COC1=CC=C(C4=NN=C(C)O4)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.84 100
ethanol 8.46 25

Preparing Stock Solutions

The following data is based on the product molecular weight 338.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.55 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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References

References are publications that support the biological activity of the product.

Saitoh et al (2009) 2-{3-[4-(alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β with good brain permeability. J.Med.Chem. 52 6270 PMID: 19775160


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View all Glycogen Synthase Kinase 3 Inhibitors

Keywords: TCS 2002, TCS 2002 supplier, TCS2002, glycogen, synthase, kinases, gsk-3, gsk3, gsk-3beta, gsk-3b, gsk-3β, inhibitors, inhibits, Glycogen, Synthase, Kinase, 3, 3869, Tocris Bioscience

1 Citation for TCS 2002

Citations are publications that use Tocris products. Selected citations for TCS 2002 include:

Bellio et al (2017) Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential. Sci Rep 7 9702 PMID: 28851980


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Literature in this Area

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