TC-G 24

Pricing Availability Delivery Time Qty
Cat.No. 4353 - TC-G 24 | C15H11ClN4O3 | CAS No. 1257256-44-2
Description: Potent and selective GSK-3β inhibitor
Chemical Name: N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent GSK-3β inhibitor (IC50 = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver glycogen reserves in rodents. Brain penetrant.

Technical Data

M. Wt 330.73
Formula C15H11ClN4O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1257256-44-2
PubChem ID 49857866
InChI Key JYCNWQGNEJYDQS-UHFFFAOYSA-N
Smiles CC(C=C3)=C(Cl)C=C3NC1=NN=C(C2=CC=C([N+]([O-])=O)C=C2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.31 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 330.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.12 mL 30.24 mL
5 mM 0.6 mL 3.02 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Khanfar et al (2010) Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J.Med.Chem. 53 8534 PMID: 21082766


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