TC-G 24

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Cat.No. 4353 - TC-G 24 | C15H11ClN4O3 | CAS No. 1257256-44-2
Description: Potent and selective GSK-3β inhibitor
Chemical Name: N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (8)
Pathways (1)

Biological Activity

Potent GSK-3β inhibitor (IC50 = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver glycogen reserves in rodents. Brain penetrant.

Technical Data

M. Wt 330.73
Formula C15H11ClN4O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1257256-44-2
PubChem ID 49857866
InChI Key JYCNWQGNEJYDQS-UHFFFAOYSA-N
Smiles CC(C=C3)=C(Cl)C=C3NC1=NN=C(C2=CC=C([N+]([O-])=O)C=C2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.31 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 330.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.24 mL 151.18 mL 302.36 mL
0.5 mM 6.05 mL 30.24 mL 60.47 mL
1 mM 3.02 mL 15.12 mL 30.24 mL
5 mM 0.6 mL 3.02 mL 6.05 mL

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References

References are publications that support the biological activity of the product.

Khanfar et al (2010) Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J.Med.Chem. 53 8534 PMID: 21082766


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Citations for TC-G 24

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

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Kinases

Kinases Product Listing

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  • MAPK Signaling
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Neurodegeneration

Neurodegeneration Product Guide

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Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Alzheimer's

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

Stem Cells

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for TC-G 24

Wnt

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.