You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for TC-G 24
TC-G 24 is a potent GSK-3β inhibitor (IC50 = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver glycogen reserves in rodents. Brain penetrant.
Technical Data for TC-G 24
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TC-G 24
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||3.31||10 with gentle warming|
Preparing Stock Solutions for TC-G 24
The following data is based on the product molecular weight 330.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||30.24 mL||151.18 mL||302.36 mL|
|0.5 mM||6.05 mL||30.24 mL||60.47 mL|
|1 mM||3.02 mL||15.12 mL||30.24 mL|
|5 mM||0.6 mL||3.02 mL||6.05 mL|
References for TC-G 24
References are publications that support the biological activity of the product.
Khanfar et al (2010) Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J.Med.Chem. 53 8534 PMID: 21082766
If you know of a relevant reference for TC-G 24, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TC-G 24, TC-G 24 supplier, TC-G24, glycogen, synthase, kinase, 3, beta, b, β, gsk3beta, gsk3β, potent, inhibits, inhibitors, selective, brain, penetrant, liver, hinge, region, binder, Glycogen, Synthase, Kinase, 4353, Tocris Bioscience
Citations for TC-G 24
Citations are publications that use Tocris products.
Currently there are no citations for TC-G 24. Do you know of a great paper that uses TC-G 24 from Tocris? Please let us know.
Reviews for TC-G 24
There are currently no reviews for this product. Be the first to review TC-G 24 and earn rewards!
Have you used TC-G 24?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.