TC-G 24

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Cat.No. 4353 - TC-G 24 | C15H11ClN4O3 | CAS No. 1257256-44-2
Description: Potent and selective GSK-3β inhibitor
Chemical Name: N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent GSK-3β inhibitor (IC50 = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver glycogen reserves in rodents. Brain penetrant.

Technical Data

M. Wt 330.73
Formula C15H11ClN4O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1257256-44-2
PubChem ID 49857866
InChI Key JYCNWQGNEJYDQS-UHFFFAOYSA-N
Smiles CC(C=C3)=C(Cl)C=C3NC1=NN=C(C2=CC=C([N+]([O-])=O)C=C2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.31 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 330.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.24 mL 151.18 mL 302.36 mL
0.5 mM 6.05 mL 30.24 mL 60.47 mL
1 mM 3.02 mL 15.12 mL 30.24 mL
5 mM 0.6 mL 3.02 mL 6.05 mL

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References

References are publications that support the biological activity of the product.

Khanfar et al (2010) Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J.Med.Chem. 53 8534 PMID: 21082766


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Citations for TC-G 24

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