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Major tanshinone isolated from Salvia miltiorrhiza. Inhibits NF-κB and AP-1 DNA binding. Exhibits cytotoxic activity in a number of different cancer cells. Inhibits β-amyloid aggregation and protects PC12 cells from β-amyloid-induced apoptosis. Displays antioxidant and anti-inflammatory properties.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||1.47||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 294.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||67.95 mL||339.74 mL||679.49 mL|
|0.25 mM||13.59 mL||67.95 mL||135.9 mL|
|0.5 mM||6.79 mL||33.97 mL||67.95 mL|
|2.5 mM||1.36 mL||6.79 mL||13.59 mL|
References are publications that support the biological activity of the product.
Lee et al (2008) Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol.Cancer Ther. 7 3527 PMID: 19001436
Wang et al (2007) Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells. J.Neurooncol. 82 11 PMID: 16955220
Jin et al (2008) Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. J.Cell Biochem. 104 15 PMID: 17979138
Dong et al (2012) Tanshinone IIA protects PC12 cells from β-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway. Mol.Biol.Rep. 39 6495 PMID: 22314911
If you know of a relevant reference for Tanshinone IIA, please let us know.
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Keywords: Tanshinone IIA, Tanshinone IIA supplier, TanshinoneIIA, tanshinone, cytotoxic, inhibitors, inhibits, nf-kappab, nf-kb, nf-κb, ap-1, dna, binding, amyloidbeta, amyloidb, amyloidβ, Antioxidants, NF-kB/IkB, Amyloid, Beta, Peptides, 4426, Tocris Bioscience
1 Citation for Tanshinone IIA
Citations are publications that use Tocris products. Selected citations for Tanshinone IIA include:
Pedersen et al (2012) RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1. J Cell Sci 125 5379 PMID: 22956547
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