2',3'-cGAMP sodium salt

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Cat.No. 5945 - 2',3'-cGAMP sodium salt | C20H22N10Na2O13P2
Description: Endogenous high affinity STING agonist
Chemical Name: 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Endogenous high affinity STING agonist (Kd values are 3.79 and 120 nM for human and rat STING, respectively). Induces repolarization of M2 macrophages in vitro.

This product is sold in units of 359μg, equivalent to 0.5μmol.

Technical Data

M. Wt 718.37
Formula C20H22N10Na2O13P2
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 71563406
InChI Key XRILCFTWUCUKJR-INFSMZHSSA-N
Smiles [H][C@]12COP(O[C@]3([C@H]([C@H](N4C=NC5=C(N=CN=C45)N)O[C@@]3(COP(O[C@@]([C@H](N6C=NC7=C6N=C(NC7=O)N)O1)([C@@H]2O)[H])(O[Na])=O)[H])O)[H])(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 35.92 50

Preparing Stock Solutions

The following data is based on the product molecular weight 718.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.78 mL 13.92 mL 27.84 mL
2.5 mM 0.56 mL 2.78 mL 5.57 mL
5 mM 0.28 mL 1.39 mL 2.78 mL
25 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Zhang et al (2013) Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol.Cell. 51 226 PMID: 23747010

Downey et al (2014) DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS One 9 e99988 PMID: 24940883

Zhang et al (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci.Rep. 5 18035 PMID: 26669264


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Keywords: 2',3'-cGAMP sodium salt, 2',3'-cGAMP sodium salt supplier, endogenous, high, affinity, STING, agonists, STING-Dependent, Signaling, 5945, Tocris Bioscience

Citations for 2',3'-cGAMP sodium salt

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Literature in this Area

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