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STK16-IN-1

Cat. No. 6036 Submit a Review Datasheet / COA / SDS
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Cat.No. 6036 - STK16-IN-1 | C17H12FN3O | CAS No. 1223001-53-3
Description: Serine/threonine protein kinase 16 (STK16) inhibitor; also inhibits PI 3Kδ, PI 3Kγ and mTOR kinases
Chemical Name: 1-(4-Fluoro-3-methylphenyl)-1,7-dihydro-2H-pyrrolo[2,3-h]-1,6-naphthyridin-2-one
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Serine/threonine protein kinase 16 (STK16) inhibitor (IC50 = 295 nM). Reduces cell number and increases accumulation of binucleated MCF-1 cells. Enhances cell apoptosis in combination with chemotherapeutics. Also inhibits PI 3-Kδ and PI-3-Kγ kinases (IC50 values are 856 and 867 nM, respectively) and mTOR kinase (IC50= 5.56 µM).

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Technical Data

M. Wt 293.3
Formula C17H12FN3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1223001-53-3
PubChem ID 58525066
InChI Key WQNRDXHKVSKUPI-UHFFFAOYSA-N
Smiles O=C(N1C2=CC(C)=C(F)C=C2)C=CC3=C1C(C=CN4)=C4N=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 293.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.41 mL 17.05 mL 34.09 mL
5 mM 0.68 mL 3.41 mL 6.82 mL
10 mM 0.34 mL 1.7 mL 3.41 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References

References are publications that support the biological activity of the product.

Liu et al (2016) Discovery of a highly selective STK16 kinase inhibitor ACS.Chem.Biol. 11 1537 PMID: 27082499

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Keywords: STK16-IN-1, STK16-IN-1 supplier, Serine/Threonine, kinase, Ser/Thr, STK16, STK16-IN-1, inhibitors, inhibits, binucleated, cells, apoptosis, chemotherapy, chemotherapeutics, PI, 3K, mTOR, Other, Kinases, 3-Kinase, 6036, Tocris Bioscience

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Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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