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Cat.No. 6036 - STK16-IN-1 | C17H12FN3O | CAS No. 1223001-53-3
Description: Serine/threonine protein kinase 16 (STK16) inhibitor; also inhibits PI 3Kδ, PI 3Kγ and mTOR kinases.
Chemical Name: 1-(4-Fluoro-3-methylphenyl)-1,7-dihydro-2H-pyrrolo[2,3-h]-1,6-naphthyridin-2-one
Purity: ≥98% (HPLC)

Biological Activity

Serine/threonine protein kinase 16 (STK16) inhibitor (IC50 = 295 nM). Reduces cell number and increases accumulation of binucleated MCF-1 cells. Enhances cell apoptosis in combination with chemotherapeutics. Also inhibits PI 3-Kδ and PI-3-Kγ kinases (IC50 values are 856 and 867 nM, respectively) and mTOR kinase (IC50= 5.56 ┬ÁM).

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Technical Data

M. Wt 293.3
Formula C17H12FN3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1223001-53-3
PubChem ID 58525066
Smiles O=C(N1C2=CC(C)=C(F)C=C2)C=CC3=C1C(C=CN4)=C4N=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.33 100
ethanol 2.93 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 293.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.41 mL 17.05 mL 34.09 mL
5 mM 0.68 mL 3.41 mL 6.82 mL
10 mM 0.34 mL 1.7 mL 3.41 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Liu et al (2016) Discovery of a highly selective STK16 kinase inhibitor ACS.Chem.Biol. 11 1537 PMID: 27082499

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Keywords: Serine/Threonine kinase Ser/Thr STK16 STK16-IN-1 inhibitors inhibits binucleated cells apoptosis chemotherapy chemotherapeutics PI 3K mTOR Other Kinases

Citations for STK16-IN-1

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Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for STK16-IN-1


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