Home / Pharmacology / Enzymes / Kinases / Other Kinases / Other Kinase Inhibitors / STK16-IN-1

STK16-IN-1

Cat. No. 6036 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 6036 - STK16-IN-1 | C17H12FN3O | CAS No. 1223001-53-3
Description: Serine/threonine protein kinase 16 (STK16) inhibitor; also inhibits PI 3Kδ, PI 3Kγ and mTOR kinases
Chemical Name: 1-(4-Fluoro-3-methylphenyl)-1,7-dihydro-2H-pyrrolo[2,3-h]-1,6-naphthyridin-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Serine/threonine protein kinase 16 (STK16) inhibitor (IC50 = 295 nM). Reduces cell number and increases accumulation of binucleated MCF-1 cells. Enhances cell apoptosis in combination with chemotherapeutics. Also inhibits PI 3-Kδ and PI-3-Kγ kinases (IC50 values are 856 and 867 nM, respectively) and mTOR kinase (IC50= 5.56 µM).

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Technical Data

M. Wt 293.3
Formula C17H12FN3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1223001-53-3
PubChem ID 58525066
InChI Key WQNRDXHKVSKUPI-UHFFFAOYSA-N
Smiles O=C(N1C2=CC(C)=C(F)C=C2)C=CC3=C1C(C=CN4)=C4N=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 293.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.41 mL 17.05 mL 34.09 mL
5 mM 0.68 mL 3.41 mL 6.82 mL
10 mM 0.34 mL 1.7 mL 3.41 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Liu et al (2016) Discovery of a highly selective STK16 kinase inhibitor ACS.Chem.Biol. 11 1537 PMID: 27082499

If you know of a relevant reference for STK16-IN-1, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Kinase Inhibitors

Keywords: STK16-IN-1, STK16-IN-1 supplier, Serine/Threonine, kinase, Ser/Thr, STK16, STK16-IN-1, inhibitors, inhibits, binucleated, cells, apoptosis, chemotherapy, chemotherapeutics, PI, 3K, mTOR, Other, Kinases, 3-Kinase, 6036, Tocris Bioscience

Citations for STK16-IN-1

Citations are publications that use Tocris products.

Currently there are no citations for STK16-IN-1. Do you know of a great paper that uses STK16-IN-1 from Tocris? Please let us know.

Reviews for STK16-IN-1

There are currently no reviews for this product. Be the first to review STK16-IN-1 and earn rewards!

Have you used STK16-IN-1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases