Serine/threonine protein kinase 16 (STK16) inhibitor (IC50 = 295 nM). Reduces cell number and increases accumulation of binucleated MCF-1 cells. Enhances cell apoptosis in combination with chemotherapeutics. Also inhibits PI 3-Kδ and PI-3-Kγ kinases (IC50 values are 856 and 867 nM, respectively) and mTOR kinase (IC50= 5.56 µM).
Sold under license from Whitehead Institute for Biomedical Research.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||2.93||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 293.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.41 mL||17.05 mL||34.09 mL|
|5 mM||0.68 mL||3.41 mL||6.82 mL|
|10 mM||0.34 mL||1.7 mL||3.41 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Liu et al (2016) Discovery of a highly selective STK16 kinase inhibitor ACS.Chem.Biol. 11 1537 PMID: 27082499
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Keywords: Serine/Threonine kinase Ser/Thr STK16 STK16-IN-1 inhibitors inhibits binucleated cells apoptosis chemotherapy chemotherapeutics PI 3K mTOR Other Kinases
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