Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC50 = 3 nM), protein kinase A (IC50 = 7 nM), p60v-src tyrosine protein kinase (IC50 = 6 nM) and CaM kinase II (IC50 = 20 nM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 50 mM in DMSO|
References are publications that support the biological activity of the product.
Ruegg and Burgess (1989) Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. TiPS 10 218 PMID: 2672462
Tamaoki et al (1986) Staurosporine, a potent inhibitor of phospholipid/Ca2+ dependent protein kinase. Biochem.Biophys.Res.Commun. 135 397 PMID: 3457562
Yanagihara et al (1991) Staurosporine: an effective inhibitor for Ca2+/calmodulin-dependent protein kinase II. J.Neurochem. 56 294 PMID: 1846174
If you know of a relevant reference for Staurosporine, please let us know.
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Keywords: Staurosporine, Staurosporine supplier, Non-Selective, protein, kinases, inhibitors, inhibits, Broad, Spectrum, Protein, Kinase, Inhibitors, 1285, Tocris Bioscience
16 Citations for Staurosporine
Citations are publications that use Tocris products. Selected citations for Staurosporine include:
Xu et al (2017) Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells. Cell Death Discov 3 16096 PMID: 28179994
Schönbrunn et al (2013) Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J Med Chem 56 3768 PMID: 23600925
Valero et al (2011) Contractile effect of tachykinins on rabbit small intestine. Acta Pharmacol Sin 32 487 PMID: 21441943
Piccart et al (2015) Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci 35 11144 PMID: 26245975
Chen et al (2016) Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells. Mol Pharmacol 11 e0156145 PMID: 27203692
Kawamoto et al (2012) Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults. PLoS One 45 58 PMID: 22124704
Dobson et al (2015) Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. Eur J Neurosci 10 e0125974 PMID: 25933382
Sonamoto et al (2015) Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ. Eneuro 5 12728 PMID: 26234946
Faulkner et al (2015) FMRP regulates neurogenesis in vivo in Xenopus laevis tadpoles. PLoS One 2 e0055 PMID: 25844398
Kondo et al (2010) Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by α-tocopherol and MEK inhibition. Braz J Med Biol Res 285 13079 PMID: 20177052
Park et al (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17 914 PMID: 27270401
Valentine et al (2014) Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses. Cell Microbiol 16 1 PMID: 23910799
Jackson et al (2013) Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. J Pharmacol Exp Ther 347 516 PMID: 24023368
Chen et al (2006) N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury. J Biol Chem 281 2764 PMID: 16314423
O'Donnell et al (2015) Interferon gamma induces protective non-canonical signaling pathways in primary neurons. J Neurochem 135 309 PMID: 26190522
Barcomb et al (2013) Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. J Biol Chem 84 834 PMID: 24056996
Do you know of a great paper that uses Staurosporine from Tocris? Please let us know.
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Literature in this Area
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