Sodium Cromoglicate

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Cat.No. 6424 - Sodium Cromoglicate | C23H14Na2O11 | CAS No. 15826-37-6
Description: Promotes ESCs/iPSCs differentiation into pancreatic endocine islet cells
Chemical Name: 5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid] disodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Promotes transformation ESCs/iPSCs into pancreatic endocrine islet cells. Facilitates differentiation from endocrine precursors. Also inhibits mast cell degranulation and histamine release. Antiasthmatic.

Technical Data

M. Wt 512.33
Formula C23H14Na2O11
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 15826-37-6
PubChem ID 27503
InChI Key VLARUOGDXDTHEH-UHFFFAOYSA-L
Smiles OC(COC1=C2C(C=C(C(O[Na])=O)OC2=CC=C1)=O)COC3=C4C(C=C(C(O[Na])=O)OC4=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25.62 50

Preparing Stock Solutions

The following data is based on the product molecular weight 512.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.76 mL 19.52 mL
5 mM 0.39 mL 1.95 mL 3.9 mL
10 mM 0.2 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Orr and Cox (1969) Disodium Cromoglycate, an inhibitor of mast cell degranulation and histamine release induced by phospholipase A. Nature. 223 197 PMID: 4183038

Kondo et al (2017) Identification of a small molecule that facilitates the differentiation of human iPSCS/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells. Diabetologia. 60 1454 PMID: 28534195


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Keywords: Sodium Cromoglicate, supplier, sodium, cromoglicate, cromoglycate, differentiation, pancreatic, islet, cells, mast, cell, degranulation, histamine, anti-asthmatic, ESCs, and, iPSC, Histaminergic-Related, Compounds, ESCs, and, iPSC, Tocris Bioscience

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