Promotes transformation ESCs/iPSCs into pancreatic endocrine islet cells. Facilitates differentiation from endocrine precursors. Also inhibits mast cell degranulation and histamine release. Antiasthmatic.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 512.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.95 mL||9.76 mL||19.52 mL|
|5 mM||0.39 mL||1.95 mL||3.9 mL|
|10 mM||0.2 mL||0.98 mL||1.95 mL|
|50 mM||0.04 mL||0.2 mL||0.39 mL|
References are publications that support the products' biological activity.
Orr and Cox (1969) Disodium Cromoglycate, an inhibitor of mast cell degranulation and histamine release induced by phospholipase A. Nature. 223 197 PMID: 4183038
Kondo et al (2017) Identification of a small molecule that facilitates the differentiation of human iPSCS/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells. Diabetologia. 60 1454 PMID: 28534195
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Keywords: Sodium Cromoglicate, supplier, sodium, cromoglicate, cromoglycate, differentiation, pancreatic, islet, cells, mast, cell, degranulation, histamine, anti-asthmatic, ESCs, and, iPSC, Histaminergic-Related, Compounds, ESCs, and, iPSC, Tocris Bioscience
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Literature in this Area
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.